Zinc and vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia

Trevino Aristarkus Pakasi, Elvina Karyadi, Ni Made Desy Suratih, Michael Salean, Nining Darmawidjaja, Hans Bor, Koos Van Der Velden, Wil Mv Dolmans, Jos Wm Van Der Meer

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Background. A previous study showed that combination of zinc and vitamin A reduced sputum conversion time in pulmonary tuberculosis (TB) patients. Objective. We studied the efficacy of which single micronutrient contributed more to the sputum conversion time. Methods. In a double-blind randomized community trial, newly sputum smear positive pulmonary TB patients were assigned randomly to receive zinc, vitamin A, zinc + vitamin A or placebo on top of TB treatment. Patients were asked to deliver their sputum on weekly basis to measure positivity of the bacteria. Nutritional status, chest x-ray, hemoglobin, C-reactive protein (CRP), retinol and zinc level were examined prior to, after 2 and 6 months of treatment. Results. Initially, 300 patients were enrolled, and 255 finished the treatment. Most patients were severely malnourished (mean BMI 16.5 2.2 Kg/m2). Patients in the zinc + vitamin A group showed earlier sputum conversion time (mean 1.9 weeks) compared with that in the other groups; however the difference was not significant. Also, no benefit could be demonstrated of any of the used supplementations on clinical, nutritional, chest x-ray, or laboratory findings. Conclusions. This study among severely malnourished TB patients, did not confirm that single or combined supplementation of zinc and vitamin A significantly reduced sputum conversion time or had other significant benefit.

Original languageEnglish
Article number41
JournalNutrition Journal
Volume9
Issue number1
DOIs
Publication statusPublished - 2010

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