Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management

Irandi Putra Pratomo, Anna Ariane, Aryo Tedjo, Rudi Heryanto, Rafika Indah Paramita

Research output: Contribution to journalReview articlepeer-review

Abstract

The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalMedical Journal of Indonesia
Volume30
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • COVID-19
  • Free radicals
  • Uric acid
  • Xanthine oxidase

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