Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

Azar Kariminia, Nicolas Durier, Gonzague Jourdain, Suneeta Saghayam, Chau V. Do, Lam Van Nguyen, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Khanh Huu Truong, Virat Sirisanthana, Vibol Ung, Saphonn Vonthanak, Jintanat Ananworanich, Nik Khairulddin Nik Yusoff, Nia Kurniati, Kamarul Azahar Razali, Moy Siew Fong, Revathy Nallusamy, Dewi Kumara Wati

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume67
Issue number1
DOIs
Publication statusPublished - 1 Sep 2014

Keywords

  • HIV
  • cohort
  • disease progression
  • pediatric
  • z score

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