Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

Azar Kariminia; Nicolas Durier; Gonzague Jourdain; Suneeta Saghayam; Chau V. Do; Lam Van Nguyen; Rawiwan Hansudewechakul; Pagakrong Lumbiganon; Kulkanya Chokephaibulkit; Khanh Huu Truong; Virat Sirisanthana; Vibol Ung; Saphonn Vonthanak; Jintanat Ananworanich; Nik Khairulddin Nik Yusoff; Nia Kurniati; Kamarul Azahar Razali; Moy Siew Fong; Revathy Nallusamy; Dewi Kumara Wati

doi:10.1097/QAI.0000000000000227

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

Azar Kariminia, Nicolas Durier, Gonzague Jourdain, Suneeta Saghayam, Chau V. Do, Lam Van Nguyen, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Khanh Huu Truong, Virat Sirisanthana, Vibol Ung, Saphonn Vonthanak, Jintanat Ananworanich, Nik Khairulddin Nik Yusoff, Nia Kurniati, Kamarul Azahar Razali, Moy Siew Fong, Revathy Nallusamy, Dewi Kumara Wati

Department of Pediatric

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

Original language	English
Pages (from-to)	71-76
Number of pages	6
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	67
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000000227
Publication status	Published - 1 Sept 2014

Keywords

HIV
cohort
disease progression
pediatric
z score

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAI.0000000000000227

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Kariminia, A., Durier, N., Jourdain, G., Saghayam, S., Do, C. V., Nguyen, L. V., Hansudewechakul, R., Lumbiganon, P., Chokephaibulkit, K., Truong, K. H., Sirisanthana, V., Ung, V., Vonthanak, S., Ananworanich, J., Nik Yusoff, N. K., Kurniati, N., Azahar Razali, K., Fong, M. S., Nallusamy, R., & Wati, D. K. (2014). Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database. Journal of Acquired Immune Deficiency Syndromes, 67(1), 71-76. https://doi.org/10.1097/QAI.0000000000000227

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title = "Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database",

abstract = "Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.",

keywords = "HIV, cohort, disease progression, pediatric, z score",

author = "Azar Kariminia and Nicolas Durier and Gonzague Jourdain and Suneeta Saghayam and Do, {Chau V.} and Nguyen, {Lam Van} and Rawiwan Hansudewechakul and Pagakrong Lumbiganon and Kulkanya Chokephaibulkit and Truong, {Khanh Huu} and Virat Sirisanthana and Vibol Ung and Saphonn Vonthanak and Jintanat Ananworanich and {Nik Yusoff}, {Nik Khairulddin} and Nia Kurniati and {Azahar Razali}, Kamarul and Fong, {Moy Siew} and Revathy Nallusamy and Wati, {Dewi Kumara}",

year = "2014",

month = sep,

day = "1",

doi = "10.1097/QAI.0000000000000227",

language = "English",

volume = "67",

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Kariminia, A, Durier, N, Jourdain, G, Saghayam, S, Do, CV, Nguyen, LV, Hansudewechakul, R, Lumbiganon, P, Chokephaibulkit, K, Truong, KH, Sirisanthana, V, Ung, V, Vonthanak, S, Ananworanich, J, Nik Yusoff, NK, Kurniati, N, Azahar Razali, K, Fong, MS, Nallusamy, R & Wati, DK 2014, 'Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database', Journal of Acquired Immune Deficiency Syndromes, vol. 67, no. 1, pp. 71-76. https://doi.org/10.1097/QAI.0000000000000227

TY - JOUR

T1 - Weight as predictors of clinical progression and treatment failure

T2 - Results from the TREAT Asia Pediatric HIV observational database

AU - Kariminia, Azar

AU - Durier, Nicolas

AU - Jourdain, Gonzague

AU - Saghayam, Suneeta

AU - Do, Chau V.

AU - Nguyen, Lam Van

AU - Hansudewechakul, Rawiwan

AU - Lumbiganon, Pagakrong

AU - Chokephaibulkit, Kulkanya

AU - Truong, Khanh Huu

AU - Sirisanthana, Virat

AU - Ung, Vibol

AU - Vonthanak, Saphonn

AU - Ananworanich, Jintanat

AU - Nik Yusoff, Nik Khairulddin

AU - Kurniati, Nia

AU - Azahar Razali, Kamarul

AU - Fong, Moy Siew

AU - Nallusamy, Revathy

AU - Wati, Dewi Kumara

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

AB - Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.

KW - HIV

KW - cohort

KW - disease progression

KW - pediatric

KW - z score

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U2 - 10.1097/QAI.0000000000000227

DO - 10.1097/QAI.0000000000000227

M3 - Article

C2 - 24872132

AN - SCOPUS:84906085101

SN - 1525-4135

VL - 67

SP - 71

EP - 76

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

IS - 1

ER -

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

Abstract

Keywords

UN SDGs

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