TY - JOUR
T1 - Volatile Compounds and Bioactivities of Non Polar Extracts of Horsfieldia macrothyrsa leaves and twigs
AU - Megawati,
AU - Darmawan, Akhmad
AU - Hudiyono, Sumi
AU - Permatasari, Vera
AU - Hidayat, Arif
AU - Hendarsyah Kurniawan, Hendris
N1 - Publisher Copyright:
© 2024 EDP Sciences. All rights reserved.
PY - 2024/3/20
Y1 - 2024/3/20
N2 - The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (nonpolar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay.
AB - The purpose of this study is to ascertain the chemical composition of Horsfieldia macrothyrsa leaves and twigs by using Gas Chromatography/Mass Spectrometry (GC/MS) to extract the hexane (nonpolar) fraction, which has antioxidant, antidiabetic, and anticancer properties against the MCF-7 breast cancer cell line. As per the findings, the primary constituents of this fraction were fatty acids and sesquiterpenes, with the other constituents being sesamin (13.32% twigs), palmitic acid (20.58% leaves), squalene (2.7% twigs), and linolenic acid (25.56% leaves). According to the antidiabetic activity test, the hexane fraction of H. macrothyrsa twigs exhibited an IC50 of 23.230 ± 0.22 μg/mL. In contrast, the antioxidant values of the leaves and twigs ranged from 50 μg/mL. The breast cancer cell line MCF-7 exhibited cytotoxic capability in an in vitro anticancer assay.
UR - http://www.scopus.com/inward/record.url?scp=85190590755&partnerID=8YFLogxK
U2 - 10.1051/e3sconf/202450307002
DO - 10.1051/e3sconf/202450307002
M3 - Conference article
AN - SCOPUS:85190590755
SN - 2555-0403
VL - 503
JO - E3S Web of Conferences
JF - E3S Web of Conferences
M1 - 07002
T2 - 9th International Symposium on Applied Chemistry in conjuction with the 5th International Conference on Chemical and Material Engineering, ISAC-ICCME 2023
Y2 - 6 December 2023 through 8 December 2023
ER -
