TY - JOUR
T1 - Vitamin D as Radiosensitizer
T2 - A Review in Cell Line
AU - Radityamurti, Fahmi
AU - Herdian, Fauzan
AU - Permata, Tiara Bunga Mayang
AU - Handoko, Handoko
AU - Kodrat, Henry
AU - Nuryadi, Endang
AU - Wibowo, Heri
AU - Gondhowiardjo, Soehartati A.
N1 - Funding Information:
This study was funded by International Publication Grant from the Universitas Indonesia (Grant number NKB-4774/UN2.RST/HKP.05.00/2020).
Publisher Copyright:
© 2020 Radityamurti et al.; Licensee SET Publisher. This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
PY - 2020
Y1 - 2020
N2 - Introduction: Vitamin D has been shown to have anti-cancer properties such as antioxidants, anti-proliferative, and cell differentiation. The property of vitamin D as an anticancer agent triggers researchers to find out whether vitamin D is useful as a radiosensitizer. Multiple studies have been carried out on cell lines in various types of cancer, but the benefits of vitamin D as a radiosensitizer still controversial. This paperwork aims to investigate the utilization of Vitamin D3 (Calcitriol) as radiosensitizer in various cell line through literature review. Methods: A systematic search of available medical literature databases was performed on in-vitro studies with Vitamin D as a radiosensitizer in all types of cell lines. A total of 11 in-vitro studies were evaluated. Results: Nine studies in this review showed a significant effect of Vitamin D as a radiosensitizer agent by promoting cytotoxic autophagy, increasing apoptosis, inhibiting of cell survival and proliferation, promoting gene in ReIB inhibition, inducing senescene and necrosis. The two remaining studies showed no significant effect in the radiosensitizing mechanism of Vitamin D due to lack of evidence in-vitro settings. Conclusion: Vitamin D have anticancer property and can be used as a radiosensitizer by imploring various mechanism pathways in various cell lines. Further research especially in-vivo settings need to be evaluated.
AB - Introduction: Vitamin D has been shown to have anti-cancer properties such as antioxidants, anti-proliferative, and cell differentiation. The property of vitamin D as an anticancer agent triggers researchers to find out whether vitamin D is useful as a radiosensitizer. Multiple studies have been carried out on cell lines in various types of cancer, but the benefits of vitamin D as a radiosensitizer still controversial. This paperwork aims to investigate the utilization of Vitamin D3 (Calcitriol) as radiosensitizer in various cell line through literature review. Methods: A systematic search of available medical literature databases was performed on in-vitro studies with Vitamin D as a radiosensitizer in all types of cell lines. A total of 11 in-vitro studies were evaluated. Results: Nine studies in this review showed a significant effect of Vitamin D as a radiosensitizer agent by promoting cytotoxic autophagy, increasing apoptosis, inhibiting of cell survival and proliferation, promoting gene in ReIB inhibition, inducing senescene and necrosis. The two remaining studies showed no significant effect in the radiosensitizing mechanism of Vitamin D due to lack of evidence in-vitro settings. Conclusion: Vitamin D have anticancer property and can be used as a radiosensitizer by imploring various mechanism pathways in various cell lines. Further research especially in-vivo settings need to be evaluated.
KW - cancer
KW - cell line
KW - radiosensitizer
KW - radiotherapy
KW - review
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85103336233&partnerID=8YFLogxK
U2 - 10.29169/1927-5951.2020.10.06.1
DO - 10.29169/1927-5951.2020.10.06.1
M3 - Article
AN - SCOPUS:85103336233
SN - 2223-3806
VL - 10
SP - 315
EP - 324
JO - Journal of Pharmacy and Nutrition Sciences
JF - Journal of Pharmacy and Nutrition Sciences
IS - 6
ER -