Vitamin C and IL-6 level during third trimester of pregnancy with preeclampsia

Metta Dewi, Saptawati Bardosono, Jeremy Rafael Tandaju

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To investigate the relationship between vitamin C intake and IL-6 level as a biomarker of oxidative stress during pregnancy. Methods: Fourty pregnant women during third trimester were grouped into preeclampsia and non-preeclampsia, and surveyed using a Food Frequency Questionnaire. The ELISA assay for IL-6 expression was performed. Univariate and bivariate analyses were conducted using SPSS software ver. 20. RESULTS: Subjects in preeclampsia group were shown to consume slightly more vitamin C than the non-preeclampsia group, with median values of 76.37 (28.05 - 96.88) mg and 68.87 (8.57 - 198.53) mg, respectively (p = 0.36). A nonparametric correlation test showed no significant association between vitamin C and total IL-6 level, with p = 0.36 and r = -0.15. There was also no difference between vitamin C consumption and IL-6 level for each group, with r = -0.14 and r = -0.20, respectively. CONCLUSIONS: There was no statistically significant association between vitamin C intake and IL-6 level in women during third trimester of pregnancy (p = 0.36).

Original languageEnglish
Pages (from-to)S90-S94
JournalJPMA. The Journal of the Pakistan Medical Association
Volume71 2)
Issue number2
Publication statusPublished - 1 Feb 2021

Keywords

  • Interleukin-6, Pre-eclampsia, Pregnancy trimesters, Ascorbic acid.

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