Vitamin B6 supplementation in pregnant women with nausea and vomiting

Noroyono Wibowo, Yuditiya Purwosunu, Akihiko Sekizawa, Antonio Farina, Victor Tambunan, Saptawati Bardosono

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Objective: To determine whether supplementation with vitamin B6 improves nausea and/or vomiting in pregnancy. Methods: This experimental study was conducted with 60 pregnant women experiencing nausea and/or vomiting prior to the 12th gestational week. Of these women, 30 were treated daily with 10 mg and the remaining 30 with 1.28 mg of pyridoxine hydrochloride for 2 weeks. The primary outcome was the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) score in each group at the end of treatment. Results: The women experiencing nausea and/or vomiting in pregnancy had significantly lower levels of circulating vitamin B6 (P = 0.007) compared with those without this symptom. Vitamin B6 supplementation significantly increased plasma vitamin B6 concentration (P < 0.05 in both groups). There were no significant differences in PUQE score or in plasma concentration levels of protein, dopamine, serotonin, unconjugated estriol, and ghrelin after supplementation between the 2 groups at baseline, but there was a significantly lesser decrease in PUQE score and a greater increase in vitamin B6 level and vitamin B6 concentration to plasma protein concentration ratios in group 1 than in group 2 after supplementation (P < 0.05 for all). Conclusion: Although the high-supplementation group had a greater decrease in PUQE score in comparison to the low-supplementation group, the difference is unlikely to affect the severity of symptoms.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
Publication statusPublished - Mar 2012


  • Nausea
  • PUQE Score
  • Pregnancy
  • Supplementation
  • Vomiting


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