Virtual screening of Indonesian flavonoid as neuraminidase inhibitor of influenza a subtype H5N1

A. A. Parikesit, Bayu Ardiansah, D. M. Handayani, Usman Sumo Friend, Djati Kirani

Research output: Contribution to journalConference articlepeer-review

7 Citations (Scopus)

Abstract

Highly Pathogenic Avian Influenza (HPAI) H5N1 poses a significant threat to animal and human health worldwide. The number of H5N1 infection in Indonesia is the highest during 2005-2013, with a mortality rate up to 83%. A mutation that occurred in H5N1 strain made it resistant to commercial antiviral agents such as oseltamivir and zanamivir, so the more potent antiviral agent is needed. In this study, virtual screening of Indonesian flavonoid as neuraminidase inhibitor of H5N1 was conducted. Total 491 flavonoid compound obtained from HerbalDB were screened. Molecular docking was performed using MOE 2008.10. This research resulted in Guajavin B as the best ligand.

Original languageEnglish
Article number012053
JournalIOP Conference Series: Materials Science and Engineering
Volume107
Issue number1
DOIs
Publication statusPublished - 5 Feb 2016
Event10th Joint Conference on Chemistry - Solo, Indonesia
Duration: 8 Sep 20159 Sep 2015

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