TY - JOUR
T1 - Virtual screening of Indonesian flavonoid as neuraminidase inhibitor of influenza a subtype H5N1
AU - Parikesit, A. A.
AU - Ardiansah, B.
AU - Handayani, D. M.
AU - Tambunan, U. S.F.
AU - Kerami, D.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2016/2/5
Y1 - 2016/2/5
N2 - Highly Pathogenic Avian Influenza (HPAI) H5N1 poses a significant threat to animal and human health worldwide. The number of H5N1 infection in Indonesia is the highest during 2005-2013, with a mortality rate up to 83%. A mutation that occurred in H5N1 strain made it resistant to commercial antiviral agents such as oseltamivir and zanamivir, so the more potent antiviral agent is needed. In this study, virtual screening of Indonesian flavonoid as neuraminidase inhibitor of H5N1 was conducted. Total 491 flavonoid compound obtained from HerbalDB were screened. Molecular docking was performed using MOE 2008.10. This research resulted in Guajavin B as the best ligand.
AB - Highly Pathogenic Avian Influenza (HPAI) H5N1 poses a significant threat to animal and human health worldwide. The number of H5N1 infection in Indonesia is the highest during 2005-2013, with a mortality rate up to 83%. A mutation that occurred in H5N1 strain made it resistant to commercial antiviral agents such as oseltamivir and zanamivir, so the more potent antiviral agent is needed. In this study, virtual screening of Indonesian flavonoid as neuraminidase inhibitor of H5N1 was conducted. Total 491 flavonoid compound obtained from HerbalDB were screened. Molecular docking was performed using MOE 2008.10. This research resulted in Guajavin B as the best ligand.
UR - http://www.scopus.com/inward/record.url?scp=84959893798&partnerID=8YFLogxK
U2 - 10.1088/1757-899X/107/1/012053
DO - 10.1088/1757-899X/107/1/012053
M3 - Conference article
AN - SCOPUS:84959893798
SN - 1757-8981
VL - 107
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - 1
M1 - 012053
T2 - 10th Joint Conference on Chemistry
Y2 - 8 September 2015 through 9 September 2015
ER -