VDAC2 (porin-2) expression pattern and localization in the bovine testis

Klaus Dieter Hinsch, Asmarinah, Elvira Hinsch, Lutz Konrad

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

In this study, sequencing of voltage-dependent anion channel 2 (VDAC2, porin-2) cDNA from bovine testis is reported. High identity to the murine, rabbit, and human subtypes at both the nucleotide and amino acid levels is demonstrated. mRNA analysis revealed expression of VDAC2 in bovine testis, whereas high levels of VDAC2 proteins were found in late spermatocytes, spermatids, and spermatozoa. In contrast, VDAC1 (porin-1) is exclusively localized in Sertoli cells. The possible role of testicular VDAC2 in providing energy metabolites and in germ cell apoptosis is discussed.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1518
Issue number3
DOIs
Publication statusPublished - 16 Apr 2001

Keywords

  • Gene expression
  • Spermatocyte
  • Spermatozoon
  • Voltage anion dependent channel 1
  • Voltage anion dependent channel 2

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