Variations in medical practice of retinopathy of prematurity among 8 Asian countries from an international survey

Young Ah Youn, Sae Yun Kim, Su Jin Cho, Yun Sil Chang, Fuyu Miyake, Satoshi Kusuda, Adhi Teguh Perma Iskandar, Rinawati Rohsiswatmo, Rizalya Dewi, Seok Chiong Chee, Siew Hong Neoh, Ma Lourdes S. Imperial, Belen Amparo E. Velasco, Bin Huey Quek, Yuh Jyh Lin, Jui Hsing Chang, Pracha Nuntnarumit, Sopapan Ngerncham, Sarayut Supapannachart, Yuri OzawaSeiichi Tomotaki, Chatchay Prempunpong, Pathaporn Prempraphan, Tetsuya Isayama

Research output: Contribution to journalArticlepeer-review


Advances in perinatal care have led to the increased survival of preterm infants with subsequent neonatal morbidities, such as retinopathy of prematurity (ROP). This study aims to compare the differences of neonatal healthcare systems, resources, and clinical practice concerning ROP in Asia with review of current literature. An on-line survey at the institutional level was sent to the directors of 336 neonatal intensive care units (NICU) in 8 collaborating national neonatal networks through the Asian Neonatal Network Collaboration (AsianNeo). ROP screening was performed in infants born at < 34 weeks in Indonesia and Japan. In South Korea, Malaysia, and Taiwan, most screened for ROP in infants born at < 32 weeks. In all networks, majority of NICUs conducted ROP screening to infants with birth weight < 1500 g. In most NICU’s in-hospital ophthalmologists performed indirect ophthalmoscopy and some were supplemented with digital imaging. Both laser photocoagulation and anti-vascular endothelial growth factor injection are performed for treatment and, vitreous surgeries are conducted less frequently in all countries. Despite limited information collected by the survey, this first study to compare ROP practices implemented in eight Asian countries through AsianNeo will enable an understanding of the differences and facilitate quality improvement by sharing better practices.

Original languageEnglish
Article number15602
JournalScientific reports
Issue number1
Publication statusPublished - Dec 2023


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