Fast vessel technology is rapidly developing with the increasing of the demands in maritime field such as military, shipping and tourism. The substantial of designing fast vessel is to create a vessel with highest speed by the lowest fuel consumption. Ship hull optimization is one of methods to reduce fuel consumption in designing the high speed vessel. The advantages of multihull vessel are huge payload, wide deck area, good stability and seakeeping, also decrease the total resistance due to wave making resistance caused by wave interference of the hulls. Multi-hulll vessel are divided by number of hulls which are catamaran, trimaran, quadramaran and pentamaran. In a research by Tuck (1998) shows that the wave resistance of catamaran, trimaran and quadramaran based on Michell's theory (classical thin ship theory) is decreasing with the increasing of number of the hulls and Froude Number at the high speed. Pentamaran hull is hulls form development of catamaran, trimaran and quadramaran which has inner and outer side hulls. This research is aim to show the effective configuration of pentamaran ship hull with inboard and outboard Asymmetric hull at outer and inner position by investigating the characteristic of total resistance at Froude Number 0.1-1 compared to symmetric pentamaran hull. Computational Fluid Dynamics (CFD) method have been performed to predict the resistance of hull-form besides its advantages is economical in time and cost. In this research, the calculation of pentamaran hull resistance is simulated by ANSYS - FLUENT (CFD Software Package). The multiphase region is separated by defining boundary air inlet as the flow of air and water inlet as the flow water in the pentamaran hull ship region. The free surface model is performed in calm water condition by Volume of Fluid (VOF) model and k-epsilon is used to simulate the turbulent viscous model. The validation data obtained from the Computational Fluid Dynamics (CFD) method were found almost similar with latest pentamaran experimental data. The result shows the coefficient resistance characteristic of Asymmetric pentamaran hull ship compare to symmetric pentamaran hull ship.