TY - JOUR
T1 - Utility of SOFA score, management and outcomes of sepsis in Southeast Asia
T2 - A multinational multicenter prospective observational study
AU - Southeast Asia Infectious Disease Clinical Research Network
AU - Lie, Khie Chen
AU - Lau, Chuen Yen
AU - Van Vinh Chau, Nguyen
AU - West, T. Eoin
AU - Limmathurotsakul, Direk
AU - Sudarmono, Pratiwi
AU - Aman, Abu Tholib
AU - Arif, Mansyur
AU - Syarif, Armaji Kamaludi
AU - Kosasih, Herman
AU - Karyana, Muhammad
AU - Chotpitayasunondh, Tawee
AU - Vandepitte, Warunee Punpanich
AU - Boonyasiri, Adiratha
AU - Lapphra, Keswadee
AU - Chokephaibulkit, Kulkanya
AU - Rattanaumpawan, Pinyo
AU - Thamlikitkul, Visanu
AU - Laongnualpanich, Achara
AU - Teparrakkul, Prapit
AU - Srisamang, Pramot
AU - Phuc, Phan Huu
AU - Hai, Le Thanh
AU - Kinh, Nguyen Van
AU - Phu, Bui Duc
AU - Hung, Nguyen Thanh
AU - Thuong, Tang Chi
AU - Tuan, Ha Manh
AU - Yen, Lam Minh
AU - Chau, Nguyen Van Vinh
AU - Thaipadungpanit, Janjira
AU - Blacksell, Stuart
AU - Day, Nicholas
AU - Ling, Claire
AU - Thwaites, Guy
AU - Wertheim, Heiman
AU - Tan, Le Van
AU - Rahman, Motiur
AU - van Doorn, H. Rogier
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/2/14
Y1 - 2018/2/14
N2 - Background: Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods: We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n=3), Thailand (n=3), and Vietnam (n=3). In patients with organ dysfunction (total SOFA score ≥2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥3 for an individual organ system. Results: From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥1500 mL fluid in 50% of patients with hypotension or lactate ≥4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p<0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p<0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62-0.74). Conclusions: Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality.
AB - Background: Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods: We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n=3), Thailand (n=3), and Vietnam (n=3). In patients with organ dysfunction (total SOFA score ≥2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥3 for an individual organ system. Results: From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥1500 mL fluid in 50% of patients with hypotension or lactate ≥4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p<0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p<0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62-0.74). Conclusions: Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality.
KW - Asia
KW - Organ dysfunction scores
KW - Patient care bundles
KW - Sepsis
KW - Southeastern
UR - http://www.scopus.com/inward/record.url?scp=85042110251&partnerID=8YFLogxK
U2 - 10.1186/s40560-018-0279-7
DO - 10.1186/s40560-018-0279-7
M3 - Article
AN - SCOPUS:85042110251
SN - 2052-0492
VL - 6
JO - Journal of Intensive Care
JF - Journal of Intensive Care
IS - 1
M1 - 9
ER -