Update of skin immunosenescence in geriatric population

Research output: Contribution to journalReview articlepeer-review


Increased life expectancy must be in line with good health and independence at the end of life. Elderly is a state when numerous factors change, including molecular, cellular, physiological, immunological, and psychosocial factors, directly causing functional impairment, inability to adapt and accumulation of various organ failures. As age advances, the immune system undergoes characteristic changes, usually resulting in decreased immune competence, termed immunosenescence. The alterations that happen in immunosenescence, including the abnormal elevation, decrease, and dysregulations of innate and adaptive immune responses, lead to more severe consequences of bacterial and viral infections, also autoimmune diseases and cancer in elderly.

Original languageEnglish
Pages (from-to)668-673
Number of pages6
JournalJournal of Pakistan Association of Dermatologists
Issue number4
Publication statusPublished - Oct 2020


  • Adaptive immune system
  • Immunosenescence
  • Innate immune system


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