Update of skin immunosenescence in geriatric population

Increased life expectancy must be in line with good health and independence at the end of life. Elderly is a state when numerous factors change, including molecular, cellular, physiological, immunological, and psychosocial factors, directly causing functional impairment, inability to adapt and accumulation of various organ failures. As age advances, the immune system undergoes characteristic changes, usually resulting in decreased immune competence, termed immunosenescence. The alterations that happen in immunosenescence, including the abnormal elevation, decrease, and dysregulations of innate and adaptive immune responses, lead to more severe consequences of bacterial and viral infections, also autoimmune diseases and cancer in elderly.