Unusual bicyclo[3.2.1]octanoid neolignans from leaves of piper crocatum and their effect on pyruvate dehydrogenase activity

Yu Juan Chai, Younghoon Go, Hai Qi Zhou, Hong Xu Li, Sun Joo Lee, Yeo Jin Park, Wahyu Widowatib, Rizal Rizal, Young Ho Kim, Seo Young Yang, Wei Li

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neo-lignan, were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated using extensive spectroscopic analyses including 1D and 2D NMR experiments and HR‐ ESI‐MS analysis, as well as through comparison with previously reported data. Two compounds were assessed for their inhibitory effect against pyruvate dehydrogenase E1α S300 phosphorylation. The fluorescent image suggested that both compounds (60 μM) revealed a stronger inhibition effect than the positive control (dichloroacetate, DCA 5 mM), with IC50 values of 99.82 μM and 80.25 μM, respectively.

Original languageEnglish
Article number1855
JournalPlants
Volume10
Issue number9
DOIs
Publication statusPublished - Sept 2021

Keywords

  • Antineoplastic cell agents
  • Neolignan
  • Piper crocatum Ruiz & Pav
  • Piperaceae

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