Unripe fruit of rubus fraxinifolius as a potential source of antioxidant and antielastase agent

Yesi Desmiaty, Berna Elya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: This research aimed to examine the anti-oxidant activity, antielastase activity, and the content of total phenolic and total flavonoid of R. fraxinifolius unripe fruit. Methods: The dried unripe fruit was extracted using Soxhlet apparatus with sequence solvent: n-hexane, ethyl acetate, and methanol. Each extract was determined the anti-oxidant and antielastase activity, total phenolic, and total flavonoid content. Result: The result showed the extracts (n-hexane, ethyl acetate, and methanol) gave anti-oxidant IC50>200; 186.84; and 19.74 ppm, and the ability of elastase inhibition was 6.84+0.9%; 52.23+7.1%; and 57.81+5.5% at 100 ppm, respectively. The methanolic extract contained phenolic 202.2 mg GAE/g extract and flavonoid 43.89 mg QE/g extract. Conclusion: R. fraxinifolius unripe fruit has shown potential as a DPPH (α, α-diphenyl-β-picrylhydrazyl) radical scavenger and anti-elastase. This study provides an excellent effect to underline the importance of R. fraxinifolius unripe fruit, and it can be developed as nutricosmetics, nutraceuticals, or herbal anti-wrinkle cosmetics.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalInternational Journal of Applied Pharmaceutics
Issue numberSpecial Issue 2
Publication statusPublished - Feb 2021


  • Anti-wrinkle
  • DPPH
  • Nutricosmetics
  • Raspberry
  • Soxhlet extraction


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