Understanding the effects of CMV on γδ T-cell populations in HIV patients starting antiretroviral therapy

Ibnu A. Ariyanto, Silvia Lee, Riwanti Estiasari, Jeanne Edmands, Budiman Bela, Amin Soebandrio, Patricia Price

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before ART and after six months, alongside healthy controls (n = 20). 50% of patients started ART with detectable CMV DNA. Proportions of Vδ2 γδ T-cells were high in patients and declined on ART, whilst proportions of Vδ2+ γδ T-cells were uniformly low, and correlated inversely with levels of CMV DNA and CMV-reactive antibody. Residual Vδ2+ cells were enriched for markers of terminal differentiation, but this did not associate with CMV metrics. Patients with CMV DNA at baseline showed a direct correlation between CMV reactive-antibody and CD8+ γδ T-cells. Our data are consistent with a role for CMV in the depletion of Vδ2+ γδ T-cells in HIV patients beginning ART, with no consistent evidence of a role for CMV in γδ T-cell activation or differentiation.

Original languageEnglish
Article number108696
JournalClinical Immunology
Volume226
DOIs
Publication statusPublished - May 2021

Keywords

  • Antiretroviral therapy
  • CMV
  • HIV
  • γδ T-cells

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