Underlying diseases and in-hospital mortality of acute respiratory failure patients: Indonesian prospective cohort study

Menaldi Rasmin, Mia Elhidsi, Prasenohadi, Wiendo Syah Putra Yahya, Yusup Subagio Sutanto, Ana Rima Setijadi, Ngakan Putu Parsama Putra, Ungky Agus Setyawan, Oea Khairsyaf, Russilawati, Deddy Herman, Mulyadi, Teuku Zulfikar, Dewi Behtri Yanifitri

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3 Citations (Scopus)


Background: Epidemiologic data of acute respiratory failure (ARF) are limited. This study aims to investigate the underlying diseases and in-hospital mortality of patients with ARF in Indonesia. Materials and Methods: An observational prospective cohort study involving patients with ARF in six hospitals was conducted. Data were collected between January and December 2017. Data on the type of ARF, quick sepsis-related organ failure assessment (qSOFA) score, underlying diseases, and in-hospital mortality were documented. Proportions were compared using Chi-square or Fisher exact tests. Multivariable regression models with variable selection based on a stepwise backward elimination were run to analyze the risk factors for in-hospital mortality. Results: A total of 412 patients (median age: 56-years-old) were included. Most of the subjects were male (66.9%), hypoxemic (55.3%), and acute onset (86.4%). The most commonly encountered underlying diseases were pneumonia (58.7%), chronic obstructive pulmonary disease (25.5%), lung tuberculosis (25.2%), lung cancer (16.5%), noncystic fibrosis bronchiectasis (11.9%), congestive heart failure (10.2%), and chronic kidney disease (CKD) (3.2%). There were 65% of patients received only oxygen therapy, invasive mechanical ventilation was utilized for 30.8% of patients, and 4.1% of patients underwent noninvasive mechanical ventilation. There were 201 (48.79%) in-hospital mortality cases. The risk factors of in-hospital mortality were qSOFA ≥2 (odds ratio [OR]: 2.420, 95% confidence interval [CI] 1.599-3.662; P = 0.000) and CKD (OR: 3.871, 95% CI 1.024-14.631; P = 0.046). Conclusions: Most of the underlying diseases of ARF in Indonesia are communicable diseases. Patients with qSOFA ≥2 and CKD have a higher risk of death during hospitality.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalJournal of Natural Science, Biology and Medicine
Issue number1
Publication statusPublished - 1 Jan 2021


  • Acute respiratory failure
  • diseases
  • in-hospital mortality


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