Uji Efek Antiartritis Ekstrak Etanol 80% Kulit Buah Delima Merah (Punica granatum L) Terhadap Udem Pada Telapak Kaki Tikus Putih Jantan yang diinduksi oleh Complete Freund’s Adjuvant

Rheumatoid arthritis is a chronic inflammatory disease that can degrade the qualityof patient survival. Conventional treatments of this disease have potentially dangerousside effects. Therefore, many patients are turning to alternative medicine usingmedicinal herbs, one of which is the fruit of Punica granatum L. The aim of thisresearch was to determine antiarthritis effect of 80% ethanolic extract of Punica granatumL. fruit peel which had been given orally on 17-30th day based on decreased edemavolume and percentage indexes of arthritis. The method was adjuvant induced arthritisby using the complete freund’s adjuvant 0,1 mL by subplantar and allowed toarthritis until day 16. The animals test were used 33 male rats of Sprague Dawleystrain that were divided into six groups: normal control, positive control, negativecontrol, and three groups had received suspension of 80% ethanolic extract of Punicagranatum L. fruit peel in 0,5% CMC at doses 20, 40, and 80 mg/200 g body weight.The Edema volume was measured by pletismometer on days 17, 20, 23, 26, 29, 31and indexes of arthritis determined on days 17 and 31. The Results showed that theywere not significant difference in the decreased edema volume and the percentageindexes of arthritis, although the percentage inhibition of edema elevated with increasingdose.