Uji Aktivitas Antibakteri 1-[(Kuinazolin-4-on-2-il)metil]piridin-1-ium Bromida dan 2-Bromometilkuinazolin-4-on

Research output: Contribution to journalArticle

Abstract

Antibacterial activity tests of quinazolin-4-one derivates: 1-[(6-nitroquinazolin-4-one- 2-yl)methyl]piridin-1-ium bromide (1), 1-[(6-aminoquinazolin-4-on-2-yl)methyl]piridin-1-um bromide (2), 2-bromomethylquinazolin-4-one (3) and 2-bromomethyl-6-nitroquinazolin-4-one (4) with trimethoprim (5) as a positive standard were conducted. The antibacterial activity tests were carried out using disc diffusion method againts E. coli, S. aureus and S. thyposa, and determination of minimum inhibitory concentration (MIC). The results showed that compounds 1 and 2 are inactive as antibacterial, whereas compounds 3 and 4 are active. The activities to E. coli were 1⁄4 times the activity of trimethoprim (MIC : 5 x 10 2 μg/ml compared to 1.25 x10 2 μg/ml ). The activity to S. typhosa were 1⁄2-1 times the activity of trimethoprim (MIC: 2.5 and 1.25x10 2 μg/ml compared to 1.25x10 2 μg/ml); but they are not active to S. aureus. Trimethoprim active to S. aureus with MIC : 0.62 x10 2 μg/ ml.
Original languageEnglish
Pages (from-to)1-8
JournalPharmaceutical Sciences and Research
Volume1
Issue number1
DOIs
Publication statusPublished - 1 Apr 2014

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