Two triterpenoids from Rubus fraxinifolius leaves and their tyrosinase and elastase inhibitory activities

Yesi Desmiaty, Muhammad Hanafi, Fadlina Chany Saputri, Berna Elya, Eko Aditya Rifai, Rezi Riadhi Syahdi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Numerous therapeutic compounds have been isolated from naturally abundant organic resources, which may offer economical and sustainable sources of compounds with safe and efficacious biological activities. In the cosmetics industry, natural compounds with anti-aging activities are eagerly sought. Thus, we prepared various extracts from Rubus fraxinifolius leaves and used enzyme inhibition assays to isolate compounds with protective effects against skin aging. Two triterpenoids were isolated from Rubus fraxinifolius Poir. leaves. The structures were characterized by spectroscopic analyses (LC-ESI-MS, 1D/2D NMR) and comparison to reported data. Compound 1 and 2 were determined as 2,3-O-ethyleneglycol, 19-hydroxyurs-12-en-23,28-dioic acid and 2,3-O-propanediol,19-hydroxyurs-12-en-28-oic acid. Methanol extract and isolates were assessed for their inhibitory effects on elastase and tyrosinase. Compounds 1 and 2 inhibited elastase with IC50 122.199 µg/mL and 98.22 µg/mL, and also inhibited tyrosinase with IC50 207.79 µg/mL and 221.51 µg/mL, respectively. The molecular docking proved that both compounds have affinities toward the enzymes.

Original languageEnglish
Article number20452
JournalScientific reports
Volume11
Issue number1
DOIs
Publication statusPublished - Dec 2021

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