Indonesia there were recorded 304.787 cases of tuberculosis that places at the third level in the world. Tuberculosis is the third level disease which caused of death after cardiovasculer and respiratori tract disease in all age groups and at the first level from all infectious disease. The residence density rate in Palembang is higher 5,84 times than ideal rate. The objective of this study is aimed to evaluate the relationship between the source of infection in house, the environment in the house, and the individual characteristic with the occurrence of lung tuberculosis BTA (+) in Palembang City. The design of this study is case control comparing case group of tuberculosis (BTA (+)) and case of control group of BTA. This study was conducted in 16 work areas of 36 health centers in Palembang. In multivariat model, it is known that the closest relationship with the occurrence of tuberculosis is nutritional status. A person who lives with high density of residence (< 4 meter/ man), male, and bad status of nutrition (body mass index, BMI > 25,1 and < 18,4) has higher risk for having tuberculosis 29 times than who has not the risk factor.