Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011–2016)

Iche A. Liberty, Nasrin Kodim, Ratu A.D. Sartika, Indang Trihandini, R. M.Suryadi Tjekyan, Zulkarnain, Masdalina Pane, Livy B. Pratisthita, Dicky L. Tahapary, Pradana Soewondo

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age. Methods: This study involved normoglycemic and prediabetes women aged 20–49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15. Results: Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875–0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807–0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812–0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890–0.926)] respectively. Conclusion: Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia.

Original languageEnglish
Article number102280
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume15
Issue number6
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • Conversion
  • Glucose
  • Reproductive
  • TyG index
  • Women

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