Background: Electronic cigarette or e-cigarette are becoming popular in worldwide, including in Indonesia. Because e-cigarette is still relatively new in Indonesia, it needs to be determined the users’ profile and ecigarette use behavior and factors associated. Methods: A population based cross-sectional survey was employed. College and university including students age 16-24 years old were involved. The survey used proportionate quota sampling to obtain a representative sample of colleges in all five districts of Yogyakarta. The questionnaire was developed based on the Indonesian version of Global Youth Tobacco Survey. The descriptive analysis was used and we investigated association between characteristics with e-cigarette use using chi-square test. Results: About 920 respondents were participated in this study. About 98 (10.68%) were current e-cigarette user, about 530 (57.61%) were also experimental cigarette smokers. About 570 (61.96%) respondents were male with average aged 20.23 years old. Most of respondents (53.26%) had university level on their formal education. There were significant relationship between e-cigarette users and sociodemographic factors such as sex (OR 1.23-3.45), knowledge about smoking as harmful (OR 1.32-3.22), attitude toward smoking (OR 1.31- 3.15), cigarette smoking (OR 1.98-5.32) and alcohol consumption (OR 1.56-3.89). Conclusion: A subtantial number of e-cigarette users among teenage is potential problem for Indonesia. More research are needed to explore other characteristic and behavior of e-cigarette users so that the government can have the whole description of e-cigarette smokers in Indonesia. Restriction of e-cigarette comsumption is one of proposed strategies for better tobacco control in Indonesia.