TY - JOUR
T1 - Treatment of Severe Dry Eye in Stevens-Johnson Syndrome with Umbilical Cord Serum Eye Drops
AU - Susiyanti, Made
AU - Kurnia, Denisa Anggi
AU - Fasha, Iqbal
AU - Irawati, Yunia
AU - Rachmadi, Lisnawati
AU - Liem, Isabella Kurnia
AU - Artini, Widya
N1 - Funding Information:
This study was made possible by funding from Universitas Indonesia through Publikasi Terindeks Internasional Sains Teknologi dan Kesehatan (PUTI Saintekes) 2020 grant with contract number NKB-2172/UN2.RST/HKP.05.00/2020. The sponsor had no involvement in any of the stages from study design to submission of the paper for publication.
Funding Information:
This study was made possible with help funding from Universitas Indonesia through Publikasi Terindeks Internasional Sains Teknologi dan Kesehatan (PUTI Saintekes) 2020 grant.
Publisher Copyright:
© 2022 Susiyanti et al.
PY - 2022
Y1 - 2022
N2 - Purpose: To evaluate the efficacy and safety of umbilical cord serum eye drops for dry eyes in ocular Stevens-Johnson Syndrome (SJS). Patients and Methods: A pre-post test study with umbilical cord serum (UCS) eye drop for ocular SJS patient with moderate to severe dry eyes. Study was conducted at Kirana Cipto Mangunkusumo General Hospital from June 2020 to December 2020. A total of five patients (five eyes) with a diagnosis of SJS more than 6 months, dry eye symptoms, and abnormal tear stability test results were included in the study. Each patient was asked to instill UCS drop into the affected eye six times daily. Evaluation of ocular symptoms with ocular surface disease index (OSDI) questionnaires, non-invasive tear break-up time (NIBUT), Schirmer I, and keratoepithelio-pathy scores was administered before applying UCS drop and at week 2 and 4 of eye drop use. Results: From June 2020 to December 2020, five eyes of five patients were evaluated in this study. Patients were aged from 22 to 71 years old with history of SJS over periods from 1 to 35 years. Three patients underwent ocular surgeries prior to the study. After four weeks of treatment, symptoms score, Schirmer I, and keratoepitheliopathy scores improved significantly, while NIBUT scores improved insignificantly. No side effects were noted during treatment. Conclusion: Administration of UCS eye drop was effective in improving symptoms and signs of dry eye in chronic SJS patients.
AB - Purpose: To evaluate the efficacy and safety of umbilical cord serum eye drops for dry eyes in ocular Stevens-Johnson Syndrome (SJS). Patients and Methods: A pre-post test study with umbilical cord serum (UCS) eye drop for ocular SJS patient with moderate to severe dry eyes. Study was conducted at Kirana Cipto Mangunkusumo General Hospital from June 2020 to December 2020. A total of five patients (five eyes) with a diagnosis of SJS more than 6 months, dry eye symptoms, and abnormal tear stability test results were included in the study. Each patient was asked to instill UCS drop into the affected eye six times daily. Evaluation of ocular symptoms with ocular surface disease index (OSDI) questionnaires, non-invasive tear break-up time (NIBUT), Schirmer I, and keratoepithelio-pathy scores was administered before applying UCS drop and at week 2 and 4 of eye drop use. Results: From June 2020 to December 2020, five eyes of five patients were evaluated in this study. Patients were aged from 22 to 71 years old with history of SJS over periods from 1 to 35 years. Three patients underwent ocular surgeries prior to the study. After four weeks of treatment, symptoms score, Schirmer I, and keratoepitheliopathy scores improved significantly, while NIBUT scores improved insignificantly. No side effects were noted during treatment. Conclusion: Administration of UCS eye drop was effective in improving symptoms and signs of dry eye in chronic SJS patients.
KW - dry eye
KW - ocular Stevens-Johnson syndrome
KW - umbilical cord serum eye drop
UR - http://www.scopus.com/inward/record.url?scp=85143493666&partnerID=8YFLogxK
U2 - 10.2147/OPTH.S385078
DO - 10.2147/OPTH.S385078
M3 - Article
AN - SCOPUS:85143493666
SN - 1177-5467
VL - 16
SP - 4089
EP - 4095
JO - Clinical Ophthalmology
JF - Clinical Ophthalmology
ER -