Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin

Aisyah Aminy Maulidina, Siti Farida

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nowadays, high-fructose/high-cholesterol diet has increased the incidence of dyslipidemia, insulin resistance, and metabolic syndrome, which are the main risk factors of non-alcoholic fatty pancreas disease (NAFPD) and may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD are currently yet to be well-understood. The use of simvastatin in managing the pancreatic disease was shown to reduce cancer risk, but it raised concerns as it was recently found to induce diabetes and worsen hyperglycaemia and A1c levels in pre-existing diabetes. Acalypha indica Linn. (AI) is known to have flavonoids and polyphenols which may decrease LDL and increase HDL level. In contrast to simvastatin, AI may control post-prandial hyperglycemia. A study on rat induced with high-fructose/high-cholesterol diet showed that AI helped reverse fatty formation in the pancreas, which was not significantly different from the rats given simvastatin. This article reviews the potential use of Acalypha indica Linn. extract as an alternative to modify the risk factors underlying NAFPD.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/TerritoryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • Acalypha indica Linn
  • cholesterol
  • fatty pancreas
  • pancreatic cancer
  • simvastatin

Fingerprint

Dive into the research topics of 'Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin'. Together they form a unique fingerprint.

Cite this