Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin

Aisyah Aminy Maulidina; Siti Farida

doi:10.1063/1.5139362

Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin

Aisyah Aminy Maulidina, Siti Farida

Department of Pharmacy Pre Clinic

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Nowadays, high-fructose/high-cholesterol diet has increased the incidence of dyslipidemia, insulin resistance, and metabolic syndrome, which are the main risk factors of non-alcoholic fatty pancreas disease (NAFPD) and may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD are currently yet to be well-understood. The use of simvastatin in managing the pancreatic disease was shown to reduce cancer risk, but it raised concerns as it was recently found to induce diabetes and worsen hyperglycaemia and A1c levels in pre-existing diabetes. Acalypha indica Linn. (AI) is known to have flavonoids and polyphenols which may decrease LDL and increase HDL level. In contrast to simvastatin, AI may control post-prandial hyperglycemia. A study on rat induced with high-fructose/high-cholesterol diet showed that AI helped reverse fatty formation in the pancreas, which was not significantly different from the rats given simvastatin. This article reviews the potential use of Acalypha indica Linn. extract as an alternative to modify the risk factors underlying NAFPD.

Original language	English
Title of host publication	4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publication	Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019
Editors	Kenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419445
DOIs	https://doi.org/10.1063/1.5139362
Publication status	Published - 10 Dec 2019
Event	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia Duration: 22 Jul 2019 → 24 Jul 2019

Publication series

Name	AIP Conference Proceedings
Volume	2193
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/Territory	Indonesia
City	Padang, West Sumatera
Period	22/07/19 → 24/07/19

Keywords

Acalypha indica Linn
cholesterol
fatty pancreas
pancreatic cancer
simvastatin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1063/1.5139362

Cite this

Maulidina, A. A., & Farida, S. (2019). Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin. In K. Lischer, T. Abuzairi, S. F. Rahman, & M. Gozan (Eds.), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019 Article 030025 (AIP Conference Proceedings; Vol. 2193). American Institute of Physics Inc.. https://doi.org/10.1063/1.5139362

Maulidina, Aisyah Aminy ; Farida, Siti. / Treatment of fatty pancreas : Acalypha indica Linn. extract as an alternative to simvastatin. 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. editor / Kenny Lischer ; Tomy Abuzairi ; Siti Fauziyah Rahman ; Misri Gozan. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

@inproceedings{307989ef8fb14833a9a063fc3426d2ea,

title = "Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin",

abstract = "Nowadays, high-fructose/high-cholesterol diet has increased the incidence of dyslipidemia, insulin resistance, and metabolic syndrome, which are the main risk factors of non-alcoholic fatty pancreas disease (NAFPD) and may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD are currently yet to be well-understood. The use of simvastatin in managing the pancreatic disease was shown to reduce cancer risk, but it raised concerns as it was recently found to induce diabetes and worsen hyperglycaemia and A1c levels in pre-existing diabetes. Acalypha indica Linn. (AI) is known to have flavonoids and polyphenols which may decrease LDL and increase HDL level. In contrast to simvastatin, AI may control post-prandial hyperglycemia. A study on rat induced with high-fructose/high-cholesterol diet showed that AI helped reverse fatty formation in the pancreas, which was not significantly different from the rats given simvastatin. This article reviews the potential use of Acalypha indica Linn. extract as an alternative to modify the risk factors underlying NAFPD.",

keywords = "Acalypha indica Linn, cholesterol, fatty pancreas, pancreatic cancer, simvastatin",

author = "Maulidina, {Aisyah Aminy} and Siti Farida",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).; 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 ; Conference date: 22-07-2019 Through 24-07-2019",

year = "2019",

month = dec,

day = "10",

doi = "10.1063/1.5139362",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Kenny Lischer and Tomy Abuzairi and Rahman, {Siti Fauziyah} and Misri Gozan",

booktitle = "4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices",

address = "United States",

}

Maulidina, AA & Farida, S 2019, Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin. in K Lischer, T Abuzairi, SF Rahman & M Gozan (eds), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019., 030025, AIP Conference Proceedings, vol. 2193, American Institute of Physics Inc., 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019, Padang, West Sumatera, Indonesia, 22/07/19. https://doi.org/10.1063/1.5139362

Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin. / Maulidina, Aisyah Aminy; Farida, Siti.
4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. ed. / Kenny Lischer; Tomy Abuzairi; Siti Fauziyah Rahman; Misri Gozan. American Institute of Physics Inc., 2019. 030025 (AIP Conference Proceedings; Vol. 2193).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Treatment of fatty pancreas

T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019

AU - Maulidina, Aisyah Aminy

AU - Farida, Siti

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Nowadays, high-fructose/high-cholesterol diet has increased the incidence of dyslipidemia, insulin resistance, and metabolic syndrome, which are the main risk factors of non-alcoholic fatty pancreas disease (NAFPD) and may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD are currently yet to be well-understood. The use of simvastatin in managing the pancreatic disease was shown to reduce cancer risk, but it raised concerns as it was recently found to induce diabetes and worsen hyperglycaemia and A1c levels in pre-existing diabetes. Acalypha indica Linn. (AI) is known to have flavonoids and polyphenols which may decrease LDL and increase HDL level. In contrast to simvastatin, AI may control post-prandial hyperglycemia. A study on rat induced with high-fructose/high-cholesterol diet showed that AI helped reverse fatty formation in the pancreas, which was not significantly different from the rats given simvastatin. This article reviews the potential use of Acalypha indica Linn. extract as an alternative to modify the risk factors underlying NAFPD.

AB - Nowadays, high-fructose/high-cholesterol diet has increased the incidence of dyslipidemia, insulin resistance, and metabolic syndrome, which are the main risk factors of non-alcoholic fatty pancreas disease (NAFPD) and may lead to pancreatic cancer. The pathogenesis and treatment of NAFPD are currently yet to be well-understood. The use of simvastatin in managing the pancreatic disease was shown to reduce cancer risk, but it raised concerns as it was recently found to induce diabetes and worsen hyperglycaemia and A1c levels in pre-existing diabetes. Acalypha indica Linn. (AI) is known to have flavonoids and polyphenols which may decrease LDL and increase HDL level. In contrast to simvastatin, AI may control post-prandial hyperglycemia. A study on rat induced with high-fructose/high-cholesterol diet showed that AI helped reverse fatty formation in the pancreas, which was not significantly different from the rats given simvastatin. This article reviews the potential use of Acalypha indica Linn. extract as an alternative to modify the risk factors underlying NAFPD.

KW - Acalypha indica Linn

KW - cholesterol

KW - fatty pancreas

KW - pancreatic cancer

KW - simvastatin

UR - http://www.scopus.com/inward/record.url?scp=85076745211&partnerID=8YFLogxK

U2 - 10.1063/1.5139362

DO - 10.1063/1.5139362

M3 - Conference contribution

AN - SCOPUS:85076745211

T3 - AIP Conference Proceedings

BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices

A2 - Lischer, Kenny

A2 - Abuzairi, Tomy

A2 - Rahman, Siti Fauziyah

A2 - Gozan, Misri

PB - American Institute of Physics Inc.

Y2 - 22 July 2019 through 24 July 2019

ER -

Maulidina AA, Farida S. Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin. In Lischer K, Abuzairi T, Rahman SF, Gozan M, editors, 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019. American Institute of Physics Inc. 2019. 030025. (AIP Conference Proceedings). doi: 10.1063/1.5139362

Treatment of fatty pancreas: Acalypha indica Linn. extract as an alternative to simvastatin

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this