Transfersome gel formulation of an ethanol extract of apples (malus domestica mill) containing antioxidants and in vitro penetration testing using franz diffusion cells

Nurarita Fadila Zesiorani, Effionora A

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Objective: This study aims to formulate and characterize a transfersome apple peel extract, formulate it into a gel, and compare it with a control gel made without transfersome. Methods: Both gels were evaluated, stability tested, and penetration tested using Franz diffusion cells on the skin of female Sprague-Dawley rats. The transfersome preparations were formulated with different concentrations of the active substance, quercetin: 0.5% (F1); 0.7% (F2), and 1.0% (F3). Results: Based on the characterization results, F1 was selected as the optimum gel formulation because it had spherical morphology, a Dmean volume of 106.44±2.70 nm, a polydispersity index of 0.078±0.01, a zeta potential of −49.96±2.05 mV, and a drug efficiency entrapment percentage of 78.78±0.46%. The cumulative amount of quercetin that was penetrated with the transfersome gel was 1514.41±26.31 µg/cm2, whereas the penetration with the control gel extract was 1133.62±18.96 µg/cm2. The cumulative percentages of the penetrated gel transfersome and gel extract were 78.40±1.89% and 49.89±0.88%, respectively. The fluxes of transfersome gel and control gel extract were 52.33±0.11 µg/cm²/hrs and 40.89±0.68 µg/cm²/hrs, respectively. Conclusions: Based on these results, it can be concluded that the gel with transfersome exhibited better penetration than the gel extract alone.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalInternational Journal of Applied Pharmaceutics
Volume9
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Apple extract gel
  • Formulation
  • Transfersome

Fingerprint Dive into the research topics of 'Transfersome gel formulation of an ethanol extract of apples (malus domestica mill) containing antioxidants and in vitro penetration testing using franz diffusion cells'. Together they form a unique fingerprint.

Cite this