Toxicity of camphorated phenol and camphorated parachlorophenol in dental pulp cell culture

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14 Citations (Scopus)

Abstract

The toxicity of phenol, parachlorophenol, camphorated phenol, camphorated parachlorophenol, and camphor was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay on established rat dental pulp cells (RPC-C2A). RPC-C2A cells at the confluent stage were incubated for 24 h in an experimental medium containing each compound at different concentrations. All tested drugs showed cytotoxicity in the MTT assay in a concentrationdependent manner. It is believed that camphor is a vehicle, and it reduces the toxicity of phenol and parachlorophenol. However, camphor itself showed cytotoxicity, and the addition of camphor increased the toxicity of phenol and parachlorophenol, reconfirming the cytotoxicity of these classical antiseptics.

Original languageEnglish
Pages (from-to)284-286
Number of pages3
JournalJournal of Endodontics
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jan 1996

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