Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy

C. Gendrin; J. Spoerk; C. Bloch; S. A. Pawiro; C. Weber; M. Figl; P. Markelj; F. Pernus; D. Georg; H. Bergmann; W. Birkfellner

doi:10.1117/12.844201

Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy

C. Gendrin, J. Spoerk, C. Bloch, S. A. Pawiro, C. Weber, M. Figl, P. Markelj, F. Pernus, D. Georg, H. Bergmann, W. Birkfellner

Department of Physics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Citations (Scopus)

Abstract

Nowadays, radiation therapy systems incorporate kV imaging units which allow for the real-time acquisition of intra-fractional X-ray images of the patient with high details and contrast. An application of this technology is tumor motion monitoring during irradiation. For tumor tracking, implanted markers or position sensors are used which requires an intervention. 2D/3D intensity based registration is an alternative, non-invasive method but the procedure must be accelerate to the update rate of the device, which lies in the range of 5 Hz. In this paper we investigate fast CT to a single kV X-ray 2D/3D image registration using a new porcine reference phantom with seven implanted fiducial markers. Several parameters influencing the speed and accuracy of the registrations are investigated. First, four intensity based merit functions, namely Cross-Correlation, Rank Correlation, Mutual Information and Correlation Ratio, are compared. Secondly, wobbled splatting and ray casting rendering techniques are implemented on the GPU and the influence of each algorithm on the performance of 2D/3D registration is evaluated. Rendering times for a single DRR of 20 ms were achieved. Different thresholds of the CT volume were also examined for rendering to find the setting that achieves the best possible correspondence with the X-ray images. Fast registrations below 4 s became possible with an inplane accuracy down to 0.8 mm.

Original language	English
Title of host publication	Medical Imaging 2010
Subtitle of host publication	Visualization, Image-Guided Procedures, and Modeling
Editors	Kenneth H. Wong, Michael I. Miga
Publisher	SPIE
ISBN (Electronic)	9780819480262
DOIs	https://doi.org/10.1117/12.844201
Publication status	Published - 1 Jan 2010
Event	Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling - San Diego, United States Duration: 14 Feb 2010 → 16 Feb 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7625
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling
Country/Territory	United States
City	San Diego
Period	14/02/10 → 16/02/10

Keywords

2D/3D registration
General purpose computations on graphics hardware
Image guided radiation therapy

Access to Document

10.1117/12.844201

Cite this

Gendrin, C., Spoerk, J., Bloch, C., Pawiro, S. A., Weber, C., Figl, M., Markelj, P., Pernus, F., Georg, D., Bergmann, H., & Birkfellner, W. (2010). Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy. In K. H. Wong, & M. I. Miga (Eds.), Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling Article 762512 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7625). SPIE. https://doi.org/10.1117/12.844201

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title = "Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy",

abstract = "Nowadays, radiation therapy systems incorporate kV imaging units which allow for the real-time acquisition of intra-fractional X-ray images of the patient with high details and contrast. An application of this technology is tumor motion monitoring during irradiation. For tumor tracking, implanted markers or position sensors are used which requires an intervention. 2D/3D intensity based registration is an alternative, non-invasive method but the procedure must be accelerate to the update rate of the device, which lies in the range of 5 Hz. In this paper we investigate fast CT to a single kV X-ray 2D/3D image registration using a new porcine reference phantom with seven implanted fiducial markers. Several parameters influencing the speed and accuracy of the registrations are investigated. First, four intensity based merit functions, namely Cross-Correlation, Rank Correlation, Mutual Information and Correlation Ratio, are compared. Secondly, wobbled splatting and ray casting rendering techniques are implemented on the GPU and the influence of each algorithm on the performance of 2D/3D registration is evaluated. Rendering times for a single DRR of 20 ms were achieved. Different thresholds of the CT volume were also examined for rendering to find the setting that achieves the best possible correspondence with the X-ray images. Fast registrations below 4 s became possible with an inplane accuracy down to 0.8 mm.",

keywords = "2D/3D registration, General purpose computations on graphics hardware, Image guided radiation therapy",

author = "C. Gendrin and J. Spoerk and C. Bloch and Pawiro, {S. A.} and C. Weber and M. Figl and P. Markelj and F. Pernus and D. Georg and H. Bergmann and W. Birkfellner",

note = "Publisher Copyright: {\textcopyright} 2010 SPIE.; Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling ; Conference date: 14-02-2010 Through 16-02-2010",

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doi = "10.1117/12.844201",

language = "English",

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Gendrin, C, Spoerk, J, Bloch, C, Pawiro, SA, Weber, C, Figl, M, Markelj, P, Pernus, F, Georg, D, Bergmann, H & Birkfellner, W 2010, Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy. in KH Wong & MI Miga (eds), Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling., 762512, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7625, SPIE, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, San Diego, United States, 14/02/10. https://doi.org/10.1117/12.844201

Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy. / Gendrin, C.; Spoerk, J.; Bloch, C. et al.
Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling. ed. / Kenneth H. Wong; Michael I. Miga. SPIE, 2010. 762512 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7625).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy

AU - Gendrin, C.

AU - Spoerk, J.

AU - Bloch, C.

AU - Pawiro, S. A.

AU - Weber, C.

AU - Figl, M.

AU - Markelj, P.

AU - Pernus, F.

AU - Georg, D.

AU - Bergmann, H.

AU - Birkfellner, W.

PY - 2010/1/1

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N2 - Nowadays, radiation therapy systems incorporate kV imaging units which allow for the real-time acquisition of intra-fractional X-ray images of the patient with high details and contrast. An application of this technology is tumor motion monitoring during irradiation. For tumor tracking, implanted markers or position sensors are used which requires an intervention. 2D/3D intensity based registration is an alternative, non-invasive method but the procedure must be accelerate to the update rate of the device, which lies in the range of 5 Hz. In this paper we investigate fast CT to a single kV X-ray 2D/3D image registration using a new porcine reference phantom with seven implanted fiducial markers. Several parameters influencing the speed and accuracy of the registrations are investigated. First, four intensity based merit functions, namely Cross-Correlation, Rank Correlation, Mutual Information and Correlation Ratio, are compared. Secondly, wobbled splatting and ray casting rendering techniques are implemented on the GPU and the influence of each algorithm on the performance of 2D/3D registration is evaluated. Rendering times for a single DRR of 20 ms were achieved. Different thresholds of the CT volume were also examined for rendering to find the setting that achieves the best possible correspondence with the X-ray images. Fast registrations below 4 s became possible with an inplane accuracy down to 0.8 mm.

AB - Nowadays, radiation therapy systems incorporate kV imaging units which allow for the real-time acquisition of intra-fractional X-ray images of the patient with high details and contrast. An application of this technology is tumor motion monitoring during irradiation. For tumor tracking, implanted markers or position sensors are used which requires an intervention. 2D/3D intensity based registration is an alternative, non-invasive method but the procedure must be accelerate to the update rate of the device, which lies in the range of 5 Hz. In this paper we investigate fast CT to a single kV X-ray 2D/3D image registration using a new porcine reference phantom with seven implanted fiducial markers. Several parameters influencing the speed and accuracy of the registrations are investigated. First, four intensity based merit functions, namely Cross-Correlation, Rank Correlation, Mutual Information and Correlation Ratio, are compared. Secondly, wobbled splatting and ray casting rendering techniques are implemented on the GPU and the influence of each algorithm on the performance of 2D/3D registration is evaluated. Rendering times for a single DRR of 20 ms were achieved. Different thresholds of the CT volume were also examined for rendering to find the setting that achieves the best possible correspondence with the X-ray images. Fast registrations below 4 s became possible with an inplane accuracy down to 0.8 mm.

KW - 2D/3D registration

KW - General purpose computations on graphics hardware

KW - Image guided radiation therapy

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M3 - Conference contribution

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BT - Medical Imaging 2010

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Gendrin C, Spoerk J, Bloch C, Pawiro SA, Weber C, Figl M et al. Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy. In Wong KH, Miga MI, editors, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling. SPIE. 2010. 762512. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.844201

Towards real-time 2D/3D registration for organ motion monitoring in image-guided radiation therapy

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