Total phenolic, UPLC-QTOF-MS analysis and antidepressant-like effect in the mice forced swim test of Jamu Neuropathic Pain Reducer

Aisyah Hanifah, Dewi Tristantini

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Neuropathic (nerve) pain is caused by damage, dysfunction or injury of nerves it will affect patient's quality of life because of chronicity and intensity. The pharmaceutical drug commonly used to treat neuropathic pain is antidepressants. However, Anti-depressant drug has dangerous side effects if consumed continuously. Herbs treatments use throughout the world for the treatment of neuropathic pain. Jamu Neuropathic Pain Reducer, which consists of aqueous multi herbs extract of nutmeg seed (Myristica fragrans), clove bud (Syzygium aromaticum) and red ginger rhizome (Zingiber officinale var rubrum) was extracted with variation temperature (60, 80, 100). This study aimed to figure out the total phenolic content (TPC) in the Jamu Neuropathic Pain Reducer used the Folin-Ciocalteu method. The highest TPC (33.58 ± 1.473mg GAE/g herb) happened at temperature 80. UPLC-QTOF-MS applied to identify the major bioactive compound in Jamu Neuropathic Pain Reducer extract used temperature extraction 80, analysis revealed the presence of compounds such as adenine, chlorogenic acid, miquelianin, quercitrin, 6-gingerol, myristicin, and eugenol. Jamu Neuropathic Pain Reducer reduced the immobility duration compared with the control negative (distilled water) (p < 0.001). The reductions of the immobility time were 8.3%, 36.4% and 30.1% for dosage 16.25 mL/kg, 32.5 mL/kg and 65 mL/kg, therefore, Jamu Neuropathic Pain Reducer had the potential to be an alternative as herbal medicine for neuropathic pain that less expensive and has minimum side effect.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/TerritoryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • antidepressant activity
  • herbs
  • neuropathic pain
  • UPLC-QTOF-MS-Analysis

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