Tolerability of fentonium bromide in indonesian volunteers

P. F. Wilmana, J. Istiantoro, A. Sinto, I. Darmansjah

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A double-blind crossover trial was carried out in 24 healthy Indonesian volunteers to assess the incidence of atropine-like side-effects after a single oral 80 mg dose of fentonium bromide compared with that after a single oral 80 mg dose of hyoscine-N-butyl bromide, and of placebo. Assessments of side-effects were made on subjective responses and objective measurements taken before, 2 hours, and 4 hours after administration of the drugs. The results showed that fentonium bromide did not produce significant atropine-like side-effects. Uyoscine-N-butyl bromide, however, did have a slight effect on pulse rate, although not of significance clinically, and produced a statistically significant, transient decrease in salivation.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalCurrent Medical Research and Opinion
Issue number3
Publication statusPublished - 1977


  • Antiulcer Agents
  • Fentonium Bromide
  • Hyoscine Butyl Bromide
  • Parasympatholytics


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