@article{548853f0bee24393ba7b952b70757846,
title = "TNF-block genotypes influence susceptibility to hiv-associated sensory neuropathy in indonesians and South Africans",
abstract = "HIV-associated sensory neuropathy (HIV-SN) is a disabling complication of HIV disease and antiretroviral therapies (ART). Since stavudine was removed from recommended treatment schedules, the prevalence of HIV-SN has declined and associated risk factors have changed. With stavudine, rs1799964*C (TNF-1031) associated with HIV-SN in Caucasians and Indonesians but not in South Africans. Here, we investigate associations between HIV-SN and rs1799964*C and 12 other polymorphisms spanning TNF and seven neighboring genes (the TNF-block) in Indonesians (n = 202; 34/168 cases) and South Africans (n = 75; 29/75 cases) treated without stavudine. Haplotypes were derived using fastPHASE and haplotype networks built with PopART. There were no associations with rs1799964*C in either population. However, rs9281523*C in intron 10 of BAT1 (alternatively DDX39B) independently associated with HIV-SN in Indonesians after correcting for lower CD4 T-cell counts and >500 copies of HIV RNA/mL (model p = 0.0011, Pseudo R2 = 0.09). rs4947324*T (between NFKBIL1 and LTA) independently associated with reduced risk of HIV-SN and African haplotype 1 (containing no minor alleles) associated with increased risk of HIV-SN after correcting for greater body weight, a history of tuberculosis and nadir CD4 T-cell counts (model: p = 0.0003, Pseudo R2 = 0.23). These results confirm TNF-block genotypes influence susceptibility of HIV-SN. However, critical genotypes differ between ethnicities and with stavudine use.",
keywords = "8.1 ancestral haplotype, DDX39B and BAT1, HIV, Sensory neuropathy, TNF-block",
author = "Jessica Gaff and Fitri Octaviana and Prinisha Pillay and Mbenda, {Huguette Gaelle Ngassa} and Gan, {June Anne} and Cherry, {Catherine L.} and Peter Kamerman and Laws, {Simon M.} and Patricia Price and ARIYANTO, {IBNU AGUS}",
note = "Funding Information: Acknowledgments: We thank the employees and patients of the POKDISUS HIV Care Clinic (Cipto Mangunkusumo Hospital) and Denise Setiawan and Ahmad Yanuar Safri for sample collection in Jakarta, Indonesia and assistance in the lab. We thank the employees and the patients of the Lenasia South Community Health Hospital, the employees of Charlotte Maxeke Academic Johannesburg Hospital for sample storage and testing and Florence Mtsweni for acting as an interpreter. We thank Lidija Milicic and Tenielle Porter of Edith Cowan University for assistance with genotyping. The authors acknowledge the support of the Australian Government Research Training Program Scholarship, Curtin University and the Curtin Health Innovation Research Institute for provision of laboratory space and technology platforms, and the Victorian Operational Infrastructure Support Program received by the Burnet Institute (CLC). Funding Information: We thank the employees and patients of the POKDISUS HIV Care Clinic (Cipto Mangunkusumo Hospital) and Denise Setiawan and Ahmad Yanuar Safri for sample collection in Jakarta, Indonesia and assistance in the lab. We thank the employees and the patients of the Lenasia South Community Health Hospital, the employees of Charlotte Maxeke Academic Johannesburg Hospital for sample storage and testing and Florence Mtsweni for acting as an interpreter. We thank Lidija Milicic and Tenielle Porter of Edith Cowan University for assistance with genotyping. The authors acknowledge the support of the Australian Government Research Training Program Scholarship, Curtin University and the Curtin Health Innovation Research Institute for provision of laboratory space and technology platforms, and the Victorian Operational Infrastructure Support Program received by the Burnet Institute (CLC). Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = jan,
day = "2",
doi = "10.3390/ijms21020380",
language = "English",
volume = "21",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}
