Title: Is iron supplementation influenced by sub-clinical inflammation?: A randomized controlled trial among adolescent schoolgirls in Myanmar

Min Kyaw Htet, Umi Fahmida, Drupadi Dillon, Arwin Akib, Budi Utomo, David I. Thurnham

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Iron absorption was impaired in the presence of sub-clinical inflammation (SCI) and might hamper the effect of iron supplementation. The purpose of the study was to identify the influence of SCI on iron supplementation. A randomized, double-blinded, placebo-controlled experimental study was conducted among anaemic adolescent schoolgirls in Ayeyarwady region, Myanmar. A total of 402 schoolgirls were recruited from six schools screened from 1269 girls who were assigned into one of four groups: Folate group (2.5 mg of folate), Vitamin A group (15,000 IU of vitamin), Iron folate group (60 mg elemental iron and folate) and Iron, and vitamin A and folate group. Supplementation was done once a week for 12 weeks. Iron, vitamin A and inflammation were measured at the baseline, middle and endline. Changes in serum ferritin and body iron were significantly higher in the IFA and IFA + vitA among those without SCI. There was interaction between vitamin A and SCI on Hb changes. Analysis of GLM repeated measure showed interactions between treatment and SCI for hemoglobin and serum transferrin receptor. Those treated with vitamin A had better outcomes when there was SCI. Inflammation accompanied a negative effect on iron supplementation and vitamin A improved efficacy of iron supplementation in the presence of SCI.

Original languageEnglish
Article number918
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Anemia
  • Iron deficiency
  • Myanmar
  • Sub-clinical inflammation

Fingerprint

Dive into the research topics of 'Title: Is iron supplementation influenced by sub-clinical inflammation?: A randomized controlled trial among adolescent schoolgirls in Myanmar'. Together they form a unique fingerprint.

Cite this