TY - JOUR
T1 - Three Indonesian clusters of H5N1 virus infection in 2005
AU - Kandun, I. Nyoman
AU - Wibisono, Hariadi
AU - Sedyaningsih, Endang R.
AU - Yusharmen,
AU - Hadisoedarsuno, Widarso
AU - Purba, Wilfried
AU - Santoso, Hari
AU - Septiawati, Chita
AU - Tresnaningsih, Erna
AU - Heriyanto, Bambang
AU - Yuwono, Djoko
AU - Harun, Syahrial
AU - Soeroso, Santoso
AU - Giriputra, Sardikin
AU - Blair, Patrick J.
AU - Jeremijenko, Andrew
AU - Kosasih, Herman
AU - Putnam, Shannon D.
AU - Samaan, Gina
AU - Silitonga, Marlinggom
AU - Chan, K. H.
AU - Poon, Leo L.M.
AU - Lim, Wilina
AU - Klimov, Alexander
AU - Lindstrom, Stephen
AU - Guan, Yi
AU - Donis, Ruben
AU - Katz, Jacqueline
AU - Cox, Nancy
AU - Peiris, Malik
AU - Uyeki, Timothy M.
PY - 2006/11/23
Y1 - 2006/11/23
N2 - Background: Since 2003, the widespread ongoing epizootic of avian influenza A (H5N1) among poultry and birds has resulted in human H5N1 cases in 10 countries. The first case of H5N1 virus infection in Indonesia was identified in July 2005. Methods: We investigated three clusters of Indonesian cases with at least two ill persons hospitalized with laboratory evidence of H5N1 virus infection from June through October 2005. Epidemiologic, clinical, and virologic data on these patients were collected and analyzed. Results: Severe disease occurred among all three clusters, including deaths in two clusters. Mild illness in children was documented in two clusters. The median age of the eight patients was 8.5 years (range, 1 to 38). Four patients required mechanical ventilation, and four of the eight patients (50%) died. In each cluster, patients with H5N1 virus infection were members of the same family, and most lived in the same home. In two clusters, the source of H5N1 virus infection in the index patient was not determined. Virus isolates were available for one patient in each of two clusters, and molecular sequence analyses determined that the isolates were clade 2 H5N1 viruses of avian origin. Conclusions: In 2005 in Indonesia, clusters of human infection with clade 2 H5N1 viruses included mild, severe, and fatal cases among family members.
AB - Background: Since 2003, the widespread ongoing epizootic of avian influenza A (H5N1) among poultry and birds has resulted in human H5N1 cases in 10 countries. The first case of H5N1 virus infection in Indonesia was identified in July 2005. Methods: We investigated three clusters of Indonesian cases with at least two ill persons hospitalized with laboratory evidence of H5N1 virus infection from June through October 2005. Epidemiologic, clinical, and virologic data on these patients were collected and analyzed. Results: Severe disease occurred among all three clusters, including deaths in two clusters. Mild illness in children was documented in two clusters. The median age of the eight patients was 8.5 years (range, 1 to 38). Four patients required mechanical ventilation, and four of the eight patients (50%) died. In each cluster, patients with H5N1 virus infection were members of the same family, and most lived in the same home. In two clusters, the source of H5N1 virus infection in the index patient was not determined. Virus isolates were available for one patient in each of two clusters, and molecular sequence analyses determined that the isolates were clade 2 H5N1 viruses of avian origin. Conclusions: In 2005 in Indonesia, clusters of human infection with clade 2 H5N1 viruses included mild, severe, and fatal cases among family members.
UR - http://www.scopus.com/inward/record.url?scp=33751216775&partnerID=8YFLogxK
U2 - 10.1056/NEJMoa060930
DO - 10.1056/NEJMoa060930
M3 - Article
C2 - 17124016
AN - SCOPUS:33751216775
VL - 355
SP - 2186
EP - 2194
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 21
ER -