Thermo-and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

Noverra Mardhatillah Nizardo; Rida Hasna Fadhilah; Ivandini Tribidasari Anggraningrum

doi:10.22146/ijc.79264

Thermo-and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

Noverra Mardhatillah Nizardo, Rida Hasna Fadhilah, Ivandini Tribidasari Anggraningrum

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) block on the thermo-and pH-responsive behavior of poly(N-isopropyl acrylamide)-block-poly[(2-dimethylamino)ethyl methacrylate)] (PNIPAM-b-PDMAEMA) was studied. The block copolymers were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization by varying the chain length of the second block (PDMAEMA).¹H-NMR and FTIR spectra confirmed the formation of block copolymers PNIPAM₂₁-b-PDMAEMA₂ and PNIPAM₂₁-b-PDMAEMA₇ with the corresponding molar masses from the GPC data. Thermo-and pH-responsive behavior of block copolymers was investigated in phosphate buffer with various pHs. Interesting results showed that the hydrophilic carboxyl end group and the hydrophobic dodecyl end group of the RAFT agent affected the resulting phase transition temperature (T_c), while the T_c was found to be low in the acidic environment. Moreover, larger particle sizes of PNIPAM₂₁-b-PDMAEMA₂ were found with a pH of 9. It is noteworthy, that the resulted block copolymers might have the potential use in a drug delivery system.

Original language	English
Pages (from-to)	449-460
Number of pages	12
Journal	Indonesian Journal of Chemistry
Volume	23
Issue number	2
DOIs	https://doi.org/10.22146/ijc.79264
Publication status	Published - 2023

Keywords

block copolymer
PDMAEMA
pH-responsive polymers
PNIPAM
thermo-responsive polymers

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10.22146/ijc.79264

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@article{c0497858e35b431780b917899548c136,

title = "Thermo-and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]",

abstract = "The influence of poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) block on the thermo-and pH-responsive behavior of poly(N-isopropyl acrylamide)-block-poly[(2-dimethylamino)ethyl methacrylate)] (PNIPAM-b-PDMAEMA) was studied. The block copolymers were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization by varying the chain length of the second block (PDMAEMA).1H-NMR and FTIR spectra confirmed the formation of block copolymers PNIPAM21-b-PDMAEMA2 and PNIPAM21-b-PDMAEMA7 with the corresponding molar masses from the GPC data. Thermo-and pH-responsive behavior of block copolymers was investigated in phosphate buffer with various pHs. Interesting results showed that the hydrophilic carboxyl end group and the hydrophobic dodecyl end group of the RAFT agent affected the resulting phase transition temperature (Tc), while the Tc was found to be low in the acidic environment. Moreover, larger particle sizes of PNIPAM21-b-PDMAEMA2 were found with a pH of 9. It is noteworthy, that the resulted block copolymers might have the potential use in a drug delivery system.",

keywords = "block copolymer, PDMAEMA, pH-responsive polymers, PNIPAM, thermo-responsive polymers",

author = "Nizardo, {Noverra Mardhatillah} and Fadhilah, {Rida Hasna} and Anggraningrum, {Ivandini Tribidasari}",

note = "Funding Information: The author would like to thank the Faculty of Mathematics and Natural Sciences Universitas Indonesia (FMIPA UI), for the research funding of Hibah Riset Penugasan FMIPA UI with contract number: 023/UN2.F3.D/PPM.00.02/2022. The authors acknowledge the NMR and DLS (particle size analyzer) facilities of the Integrated Laboratory and Research Center (ILRC) Universitas Indonesia. Noteworthy, the authors thank Dody Andi Winarto, B.Eng., M.Eng. from Badan Riset Inovasi Nasional (BRIN) for his support in facilitating the Gel Permeation Chromatography analysis in BRIN. Publisher Copyright: {\textcopyright} 2023, Gadjah Mada University. All rights reserved.",

year = "2023",

doi = "10.22146/ijc.79264",

language = "English",

volume = "23",

pages = "449--460",

journal = "Indonesian Journal of Chemistry",

issn = "1411-9420",

publisher = "Gadjah Mada University",

number = "2",

}

TY - JOUR

T1 - Thermo-and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

AU - Nizardo, Noverra Mardhatillah

AU - Fadhilah, Rida Hasna

AU - Anggraningrum, Ivandini Tribidasari

N1 - Funding Information: The author would like to thank the Faculty of Mathematics and Natural Sciences Universitas Indonesia (FMIPA UI), for the research funding of Hibah Riset Penugasan FMIPA UI with contract number: 023/UN2.F3.D/PPM.00.02/2022. The authors acknowledge the NMR and DLS (particle size analyzer) facilities of the Integrated Laboratory and Research Center (ILRC) Universitas Indonesia. Noteworthy, the authors thank Dody Andi Winarto, B.Eng., M.Eng. from Badan Riset Inovasi Nasional (BRIN) for his support in facilitating the Gel Permeation Chromatography analysis in BRIN. Publisher Copyright: © 2023, Gadjah Mada University. All rights reserved.

PY - 2023

Y1 - 2023

N2 - The influence of poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) block on the thermo-and pH-responsive behavior of poly(N-isopropyl acrylamide)-block-poly[(2-dimethylamino)ethyl methacrylate)] (PNIPAM-b-PDMAEMA) was studied. The block copolymers were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization by varying the chain length of the second block (PDMAEMA).1H-NMR and FTIR spectra confirmed the formation of block copolymers PNIPAM21-b-PDMAEMA2 and PNIPAM21-b-PDMAEMA7 with the corresponding molar masses from the GPC data. Thermo-and pH-responsive behavior of block copolymers was investigated in phosphate buffer with various pHs. Interesting results showed that the hydrophilic carboxyl end group and the hydrophobic dodecyl end group of the RAFT agent affected the resulting phase transition temperature (Tc), while the Tc was found to be low in the acidic environment. Moreover, larger particle sizes of PNIPAM21-b-PDMAEMA2 were found with a pH of 9. It is noteworthy, that the resulted block copolymers might have the potential use in a drug delivery system.

AB - The influence of poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) block on the thermo-and pH-responsive behavior of poly(N-isopropyl acrylamide)-block-poly[(2-dimethylamino)ethyl methacrylate)] (PNIPAM-b-PDMAEMA) was studied. The block copolymers were synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization by varying the chain length of the second block (PDMAEMA).1H-NMR and FTIR spectra confirmed the formation of block copolymers PNIPAM21-b-PDMAEMA2 and PNIPAM21-b-PDMAEMA7 with the corresponding molar masses from the GPC data. Thermo-and pH-responsive behavior of block copolymers was investigated in phosphate buffer with various pHs. Interesting results showed that the hydrophilic carboxyl end group and the hydrophobic dodecyl end group of the RAFT agent affected the resulting phase transition temperature (Tc), while the Tc was found to be low in the acidic environment. Moreover, larger particle sizes of PNIPAM21-b-PDMAEMA2 were found with a pH of 9. It is noteworthy, that the resulted block copolymers might have the potential use in a drug delivery system.

KW - block copolymer

KW - PDMAEMA

KW - pH-responsive polymers

KW - PNIPAM

KW - thermo-responsive polymers

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U2 - 10.22146/ijc.79264

DO - 10.22146/ijc.79264

M3 - Article

AN - SCOPUS:85158932219

SN - 1411-9420

VL - 23

SP - 449

EP - 460

JO - Indonesian Journal of Chemistry

JF - Indonesian Journal of Chemistry

IS - 2

ER -

Thermo-and pH-Responsive Behavior of Poly(N-isopropylacrylamide)-Block-Poly[(2-dimethylamino)ethyl Methacrylate]

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Keywords

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