Pain management for patients by nurses refers to medical therapy and pharmacological approaches. This study aimed to determine the effect of therapeutic touch on post-operative pain. This study used a quasi-experimental design conducted on 60 respondents, comprised 30 person for intervention group (therapeutic touch) and 30 person for control group (deep-breaths technique). The study conducted in the surgical ward for adult patients at Pasar Rebo Hospital Jakarta. Data collected from April until October 2012. The result of Wilcoxon Signed Ranks test showed a significant difference between the pain scale before and after treatment either the intervention group or the control group (p value = 0.000). The Mann-Whitney test’s result also showed a significant difference in pain reduction between the scale of the intervention group with the control group (p value = 0.000).