The use of Lysozyme Toothpaste to Prevent Early Childhood Caries (Ecc) in 2 Years Old Children

Essie Octiara, Heriandi Sutadi, Yahwardiah Siregar, Ameta Primasari

Research output: Contribution to journalArticlepeer-review


The aim was to analyze the effect of using non-fluoride lysozyme toothpaste for five weeks against ECC prevention, which was evaluated from deft and defs records, S.mutans colonies, sIgA, and lysozyme activity in 2-years-old children. This investigation is a clinical trial with 68 children aged 14-35 months, including 29 children without caries and 39 ECC. Dental examination and saliva were taken before and after using toothpaste. Saliva was reviewed to discover the amount of S. mutans, sIgA, and lysozyme activity. sIgA was evaluated by ELISA, and lysozyme activity by spectrophotometry. Data interpretation is determined using paired and unpaired t-test. The amount of S.mutans colonies in saliva following lysozyme toothpaste in the ECC group decreased significantly. After using lysozyme toothpaste, there was a higher decrease in sIgA in ECC than the control group. After using lysozyme toothpaste, the highest increase in lysozyme activity was found in ECC children. Lysozyme toothpaste can reduce the increase in defs index by 50% in ECC compared to the control group. Lysozyme toothpaste can prevent ECC, marked by the reduction in defs index, the amount of S.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 2022


  • Ecc
  • Lysozyme activity
  • Lysozyme toothpaste
  • S.mutans
  • Siga


Dive into the research topics of 'The use of Lysozyme Toothpaste to Prevent Early Childhood Caries (Ecc) in 2 Years Old Children'. Together they form a unique fingerprint.

Cite this