Dengue hemorrhagic fever (DHF) constitutes a significant public health problem in Jakarta, thus it is crucial to plan preventive measure before an outbreak occurs.The aim of the study was to find the trend of DHF cases in Central Jakarta. Subjects were diagnosed for DHF in Central Jakarta from 2008 to 2010, and were documented by Sudinkes (District Health Office) of Central Jakarta. Investigation was conducted on the trend of DHF cases using secondary data, while adjusting for several criteria such as age, gender and case fatality rate (CFR).The results showed that peak incidence of DHF infections was detected in May 2008, and in March 2009 and 2010. There was no difference observed between male and female (p<0.19), whereas adult personnels were more susceptible to suffer from DHF compared to children (p<0.001). CFR appeared to be under the standard (<1%).CFR of DHF in Jakarta has to be maintained as of <1%. This can be done by conducting several efforts on decreasing of DHF cases. To conclude, all societies living in the area of Central Jakarta should be aware of DHF and the awareness has to be raised particularly from March until May.