TY - JOUR
T1 - The treatment of tuberculous meningitis in children with a combination of isoniazid, rifampicin and streptomycin (a preliminary report)
AU - Rahajoe, N. N.
AU - Rahajoe, N.
AU - Boediman, I.
AU - Said, Mardjanis
AU - Lazuardi, S.
PY - 1979
Y1 - 1979
N2 - 22 cases of tuberculous meningitis have been treated with isoniazid, streptomycin and rifampicin, and 19 cases with isoniazid, P.A.S. and streptomycin. Both groups received corticosteroid at the beginning of the treatment. The 2 groups were compared on the clinical and neurological improvement, duration of necessary hospitalization, the presence of sequelae, and the death rate. Also, the tolerability of both regimens was compared. It seemed that rifampicin shortened the necessary hospital stay. It was also found that sequelae were less in the rifampicin group than in the standard regimen group. There was no obvious difference in the mortality rate of both groups, which might be due to the fact that the cases were of the advanced stage. Anticonvulsants might influence the high incidence of liver dysfunction, as could be seen in the high incidence of jaundice in the rifampicin group. The cases are still being followed up for 13 months or more to obtain a final conclusion.
AB - 22 cases of tuberculous meningitis have been treated with isoniazid, streptomycin and rifampicin, and 19 cases with isoniazid, P.A.S. and streptomycin. Both groups received corticosteroid at the beginning of the treatment. The 2 groups were compared on the clinical and neurological improvement, duration of necessary hospitalization, the presence of sequelae, and the death rate. Also, the tolerability of both regimens was compared. It seemed that rifampicin shortened the necessary hospital stay. It was also found that sequelae were less in the rifampicin group than in the standard regimen group. There was no obvious difference in the mortality rate of both groups, which might be due to the fact that the cases were of the advanced stage. Anticonvulsants might influence the high incidence of liver dysfunction, as could be seen in the high incidence of jaundice in the rifampicin group. The cases are still being followed up for 13 months or more to obtain a final conclusion.
UR - http://www.scopus.com/inward/record.url?scp=0018561757&partnerID=8YFLogxK
U2 - 10.14238/pi19.11-12.1979.285-94
DO - 10.14238/pi19.11-12.1979.285-94
M3 - Article
C2 - 537822
AN - SCOPUS:0018561757
VL - 19
SP - 285
EP - 294
JO - Paediatrica Indonesiana
JF - Paediatrica Indonesiana
SN - 2338-476X
IS - 11-12
ER -