TY - JOUR
T1 - The Therapeutic Potentials of Intermittent Hypoxia on Bone Healing
T2 - A Systematic Review
AU - Kismanto,
AU - Setiawan, Krisnadi
AU - Setyaningsih, Agustina
AU - Sari, Dewi Nirmala
AU - Maulina, Tantry
AU - Mulyawan, Wawan
AU - rezano, Andri
AU - Priosoeryanto, Bambang Pontjo
AU - Yusuf, Harmas Yazid
N1 - Publisher Copyright:
© (2022), (University of Dicle). All Rights Reserved.
PY - 2022
Y1 - 2022
N2 - The use of a low dose intermittent hypoxia is a potential strategy for the implementation of the nonpharmacological method to cure the bone disease. However, nowadays there havent reached a strong scientific consensus on the bone metabolism process against the hypoxia. Though, there are roles of HIF-1α, VEGF and mRNA which can accelerate the bone healing. This research aims to analyze the IH’s potential therapeutic of the healing process against the bone fracture.PubMed, Google Scholar, Dentistry and Oral Sciences, CINAHL are online databases to search the experimental study data in English which inquiry on the intermittent hypoxia effectiveness in the bone fracture healing. Two studies on male animals with bone injury using continuous therapy method of IH. The increase of HIF-1α, VEGF, and mRNA expressions is inversely proportional to the bone fracture healing. Based on this systemic review, intermittent hypoxia may promote bone healing. Evidenced by increased bone formation, bone mass, and bone strength. However, the additional research is still needed for the optimal duration for bone regeneration and maintance of anatomically shaped bone grafts in the bone regeneration process.
AB - The use of a low dose intermittent hypoxia is a potential strategy for the implementation of the nonpharmacological method to cure the bone disease. However, nowadays there havent reached a strong scientific consensus on the bone metabolism process against the hypoxia. Though, there are roles of HIF-1α, VEGF and mRNA which can accelerate the bone healing. This research aims to analyze the IH’s potential therapeutic of the healing process against the bone fracture.PubMed, Google Scholar, Dentistry and Oral Sciences, CINAHL are online databases to search the experimental study data in English which inquiry on the intermittent hypoxia effectiveness in the bone fracture healing. Two studies on male animals with bone injury using continuous therapy method of IH. The increase of HIF-1α, VEGF, and mRNA expressions is inversely proportional to the bone fracture healing. Based on this systemic review, intermittent hypoxia may promote bone healing. Evidenced by increased bone formation, bone mass, and bone strength. However, the additional research is still needed for the optimal duration for bone regeneration and maintance of anatomically shaped bone grafts in the bone regeneration process.
KW - fracture healing
KW - HIF-1α
KW - IH therapeutic
KW - VEGF and mRNA
KW - İntermittent hypoxia
UR - http://www.scopus.com/inward/record.url?scp=85173438950&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:85173438950
SN - 1309-100X
VL - 15
SP - 1838
EP - 1844
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 4
ER -