Derivatives of Spirooxindole compounds with the peculiarities of a heterocylic ring-shaped framework, therefore these compounds have biological activities that play an important role in the pharmaceutical field. The synthesis of spirooxindole derivates was successfully carried out with the Multicomponent reaction that plays a role in it is the Knovenagel condensation reaction and followed by Michael's addition reaction. The derivative reaction of spirooxindole compounds is more effective and efficient in synthesis time because the reaction uses a heterogeneous catalyst of TiO2/SiO2 nanoparticles. In this research we will compare using TiO2 and nano TiO2/SiO2 as catalyst. This study produced a spirooxindole compound derivative using precursors such as, isatin, malononitrile and 1,3-diketone groups varied with baribituric acid. The results of the reaction optimization obtained that reaction time of 60 minutes, at temperature of 50 ° C, and a catalyst load of 12.5%. The yield percentage obtained under optimum conditions was found 82,72% in TiO2 catalyst and then 86, 81% in TiO2/SiO2 catalyst. The yield was obtained after the compound was recrystallized using hot ethanol. The characterization of TiO2 and TiO2/SiO2 catalysts was confirmed using FT-IR, XRD, and SEM-EDX. While the characterization of the spirooxindole compound derivate products was confirmed by TLC, FT-IR, and UV-Vis.
|Journal||Journal of Physics: Conference Series|
|Publication status||Published - 14 Jun 2021|
|Event||7th International Conference on Mathematics, Science, and Education 2020, ICMSE 2020 - Semarang, Virtual, Indonesia|
Duration: 6 Oct 2020 → 6 Oct 2020