The study of zinc oxide addition into hydroxyapatite/chitosan scaffold for bone tissue engineering application

Akhmad Herman Yuwono, Ghiska Ramahdita, Muhammad Aldi Mu'Lanuddin, Alyssa Adyandra, Gifrandy Gustiraharjo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Citations (Scopus)

Abstract

Hydroxyapatite (HAp) and chitosan (CS) are known to be suitable to be used as the main matrices in scaffold fabrication due to its biodegradability and biocompatibility. However, biocompatibility contributes to the growth and development of bacteria. Therefore, the properties of these scaffolds can be improved by adding additional substance to the scaffold. In this study, antibacterial property was improved by adding zinc oxide into HAp/CS scaffold with concentration of 1%, 2%, and 3% by weight. These scaffolds were fabricated through freeze drying techniques in -80°C. Chemical analysis, microstructure, and phase composition of these scaffolds were gone trough Fourier Transform Infra Red (FTIR), Scanning Electron Microscope (SEM), and Energy Dispersive X-Ray Analisis (EDX) assays. Antibacterial examination was also carried out to study zinc oxide ability to inhibit bacteria growth in HAp/CS. These scaffolds showed antibacterial efficacy against Escherichia coli. In this analysis, zinc oxide concentration has a linear correlation to antibacterial activity, where each 1%, 2%, and 3% ZnO have inhibition zone diameter of 0.25, 0.5, and 0.75 mm, respectively. This study showed a simple approach for developing bone scaffold with the addition of zinc oxide to enhance its antibacterial activity.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Country/TerritoryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • Antibacterial Activity
  • Bone Scaffold
  • Chitosan
  • Freeze Drying
  • Hydroxyapatite
  • Zinc Oxide

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