A set of nanoparticles NdSrMnO3 has been prepared base on sol-gel method. On A site, the nanoparticles were modified by substitution among Nd and Sr. The effect of substitution on A site of sample to the structural and morphological were entirely examined by mean of X-Ray Diffractometer (XRD) and Scanning Electron Microscopy (SEM). From XRD result, it is found that all the sample under investigated show orthorhombic structure indicating that A site substitution does not modify structure. On the other hand, some morphological behavior has been proposed as A site is substituted. The shape and size of sample are significantly different, resulting A site substitution succeed to influenced morphology of nanosized particles.