The stent thrombosis in Belgium (STIB) scoring system reliability in Indonesia patients and the modified STIB scoring (M-STIB)

Rakhmad Hidayat, Al Rasyid, Salim Harris, Alida R. Harahap, Herqutanto, Melva Louisa, Erlin Listiyaningsih, Aldy Safruddin Rambe, Tonny Loho

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Clopidogrel is recommended as an alternative to Acetyl Salicylic Acid (ASA), the first-line drug for secondary stroke prevention. Clopidogrel resistance in Indonesia is reportedly 15.8%. The Stent Thrombosis in Belgium (STIB) is a scoring system proposed to assess clopidogrel resistance which has not been tested for the reliability in Indonesian population. Objectives: The objective of the study is to test the reliability of the STIB scoring and modified-STIB scoring system in Indonesian population. Methods: This study was conducted cross-sectionally in Dr. Cipto Mangunkusumo Hospital and Universitas Indonesia Hospital from January 2020 to December 2021. Laboratory examinations of human CYP450 concentration in blood plasma from 112 subjects were carried out using the ELISA method. The clopidogrel resistance test was carried out using the VerifyNow method. Results: Out of 112 ischemic stroke patients in this study, 14.3% of them did not respond to clopidogrel. Cross-tabulation between the STIB score and clopidogrel resistance showed significant results (p < 0.05) on the Hb variable and a combination of two or three factors involving Hb levels. Both Hb and CYP450 levels can be independent factors predicting clopidogrel resistance. Once combined, the Hb and CYP450 cutoff levels of 458.9 pg/mL had a sensitivity of 100% with a specificity of 30.2%. Conclusions: STIB scoring system did not prove to be reliable in screening for Clopidogrel resistance in Indonesian population. The modified STIB scoring system proposed in this study showed a promising result. Further research with larger population should be conducted.

Original languageEnglish
Article number108
JournalEgyptian Journal of Neurology, Psychiatry and Neurosurgery
Volume59
Issue number1
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Clopidogrel resistance
  • CYP450
  • Modified STIB
  • STIB
  • Stroke

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