Gender inequality in the use of space has been going on for a long time. Men are identified with income-earning activities (traveling and working) while women are associated with domestic work. However, there has been a transition in the economic world where today women have the right to work in the office. Even so, men and women have different needs and physical characteristics. One of the periodic psychological processes experienced by women is the menstrual events that have a certain impact on mood changes and behavior that will affect their spatial needs and performance of female employees. This paper is a preliminary study to overview the effectiveness of spatial organizations in accommodating menstruating women while working. Case studies were carried out in an office room in skyscrapers with interview methods and observations of interior elements. The research focused on observing the impact of atmosphere and colors towards women's menstrual cycle that leads to depression- related to how women occupy spaces. The expected results are a comprehensive assessment of the current state of office space in accommodating specific needs.