The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition

Badriul Hegar, Yulianti Wibowo, Ray Wagiu Basrowi, Reza Gunadi Ranuh, Subianto Marto Sudarmo, Zakiudin Munasir, Alpha Fardah Atthiyah, Ariani Dewi Widodo, Supriatmo, Muzal Kadim, Ahmad Suryawan, Ninung Rose Diana, Christy Manoppo, Yvan Vandenplas

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.

Original languageEnglish
Pages (from-to)330-340
Number of pages11
JournalPediatric Gastroenterology, Hepatology and Nutrition
Volume22
Issue number4
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • 2'-fucosyllactose
  • Breast feeding
  • Human milk
  • Infant
  • Lacto-N-neotetraose
  • Oligosaccharide

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