The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition

Badriul Hegar; Yulianti Wibowo; Ray Wagiu Basrowi; Reza Gunadi Ranuh; Subianto Marto Sudarmo; Zakiudin Munasir; Alpha Fardah Atthiyah; Ariani Dewi Widodo; Supriatmo; Muzal Kadim; Ahmad Suryawan; Ninung Rose Diana; Christy Manoppo; Yvan Vandenplas

doi:10.5223/pghn.2019.22.4.330

The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition

Badriul Hegar, Yulianti Wibowo, Ray Wagiu Basrowi, Reza Gunadi Ranuh, Subianto Marto Sudarmo, Zakiudin Munasir, Alpha Fardah Atthiyah, Ariani Dewi Widodo, Supriatmo, Muzal Kadim, Ahmad Suryawan, Ninung Rose Diana, Christy Manoppo, Yvan Vandenplas

Department of Pediatric

Research output: Contribution to journal › Review article › peer-review

90 Citations (Scopus)

Abstract

Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.

Original language	English
Pages (from-to)	330-340
Number of pages	11
Journal	Pediatric Gastroenterology, Hepatology and Nutrition
Volume	22
Issue number	4
DOIs	https://doi.org/10.5223/pghn.2019.22.4.330
Publication status	Published - 1 Jan 2019

Keywords

2'-fucosyllactose
Breast feeding
Human milk
Infant
Lacto-N-neotetraose
Oligosaccharide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5223/pghn.2019.22.4.330

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Hegar, B., Wibowo, Y., Basrowi, R. W., Ranuh, R. G., Sudarmo, S. M., Munasir, Z., Atthiyah, A. F., Widodo, A. D., Supriatmo, Kadim, M., Suryawan, A., Diana, N. R., Manoppo, C., & Vandenplas, Y. (2019). The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition. Pediatric Gastroenterology, Hepatology and Nutrition, 22(4), 330-340. https://doi.org/10.5223/pghn.2019.22.4.330

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title = "The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition",

abstract = "Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.",

keywords = "2'-fucosyllactose, Breast feeding, Human milk, Infant, Lacto-N-neotetraose, Oligosaccharide",

author = "Badriul Hegar and Yulianti Wibowo and Basrowi, {Ray Wagiu} and Ranuh, {Reza Gunadi} and Sudarmo, {Subianto Marto} and Zakiudin Munasir and Atthiyah, {Alpha Fardah} and Widodo, {Ariani Dewi} and Supriatmo and Muzal Kadim and Ahmad Suryawan and Diana, {Ninung Rose} and Christy Manoppo and Yvan Vandenplas",

note = "Publisher Copyright: {\textcopyright} 2019 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.",

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month = jan,

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doi = "10.5223/pghn.2019.22.4.330",

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Hegar, B, Wibowo, Y, Basrowi, RW, Ranuh, RG, Sudarmo, SM, Munasir, Z, Atthiyah, AF, Widodo, AD, Supriatmo, Kadim, M, Suryawan, A, Diana, NR, Manoppo, C & Vandenplas, Y 2019, 'The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition', Pediatric Gastroenterology, Hepatology and Nutrition, vol. 22, no. 4, pp. 330-340. https://doi.org/10.5223/pghn.2019.22.4.330

TY - JOUR

T1 - The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition

AU - Hegar, Badriul

AU - Wibowo, Yulianti

AU - Basrowi, Ray Wagiu

AU - Ranuh, Reza Gunadi

AU - Sudarmo, Subianto Marto

AU - Munasir, Zakiudin

AU - Atthiyah, Alpha Fardah

AU - Widodo, Ariani Dewi

AU - Supriatmo,

AU - Kadim, Muzal

AU - Suryawan, Ahmad

AU - Diana, Ninung Rose

AU - Manoppo, Christy

AU - Vandenplas, Yvan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.

AB - Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.

KW - 2'-fucosyllactose

KW - Breast feeding

KW - Human milk

KW - Infant

KW - Lacto-N-neotetraose

KW - Oligosaccharide

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U2 - 10.5223/pghn.2019.22.4.330

DO - 10.5223/pghn.2019.22.4.330

M3 - Review article

AN - SCOPUS:85070300982

SN - 2234-8646

VL - 22

SP - 330

EP - 340

JO - Pediatric Gastroenterology, Hepatology and Nutrition

JF - Pediatric Gastroenterology, Hepatology and Nutrition

IS - 4

ER -

The role of two human milk oligosaccharides, 2'-fucosyllactose and lacto-N-neotetraose, in infant nutrition

Abstract

Keywords

UN SDGs

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