The role of HLA-antigens in prurigo hebra

Siti Aisah Boediarda, S. Moeslichan, Santoso Comain, Unandar Budimulja, Adhi Djuanda

Research output: Contribution to journalArticlepeer-review


Class-1 human leucocyte antigens (HLA) group A and B have been investigated and associated with various skin diseases, such as psoriasis, herpetiformis dermatitis of During, and lupus erythematosus. In earlier study, the genetic inheritance of prurigo Hebra (PH) has been analyzed and it followed the pattern of multifactorial trait Alt of PH patients had hypersensitivity reactions to insect bite. These findings assumed that HLA antigens might have an association with PH. The purpose of this study is to investigate Class-1 HLA antigens in PH patients. An unmatched case-control study was performed in 41 patients with PH and 41 normal healthy persons (control group). The class I-HLA was investigated based on microlympho cytotoxicity method using Terasaki plate completed with Class-1 HLA antigens for Asian (One Lambda, USA 1997). From the antigen frequency (fa) of HLA investigation, HLA-A9 (fa=0.646) and HLA-B15 (fa=0.548) types, were found more frequent among the population study (n=82), and it was consistent with the characteristics of class I-HLA types of the Indonesian population. In this study HLA-A10 was found significantly more frequent in PH patients than in the control group (RR-8.0 with 95% CI 1.67; 8.87). HLA-A10 was concluded as a risk factor for PH, with the etiologic fraction 25.60%. HLA-A6602(10) and HLA-B27 were significantly found as risk factors that influenced the development of mild PH (RR=0.10 with 95% CI. 0.01; 0.95). Individuals with HLA-B63(15) clinically tend to develop severe PH (RR=5.55, although statistically was not significant). Interestingly, HLA-B35 was found more frequent in the control group than in PH patients (RR=0.17, 95% CI. 0.04;0.65). HLA-B35 was concluded to be a significant protective factor for the development of PH. litis study proved that HLA antigens are associated with PH and influence the severity of the disease. The polymorphic genes (multigenes) of HLA found in this study supported the theory that PH inheritance pattern is compatible with the multifactorial pattern.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalMedical Journal of Indonesia
Issue number4
Publication statusPublished - 1 Oct 2000


  • HLA
  • HLA-A10
  • HLA-B35
  • Protective factor
  • Prurigo Hebra
  • Risk factor


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