The Role of H+ in Emerging Muscle Fatigue: It Influence in Skeletal - Muscle of Rana Sp

Fanny Septiani Farhan, Ermita I. Ilyas, Mohamad Sadikin

Research output: Contribution to journalArticlepeer-review


Fatigue describes a condition in which a muscle is no longer able to generate or sustain the expected power output. Some suggested that lactic acid accumulation play a role ini fatic. On the their had increase concentration of hydrogen ions and a decrease in pH (increase in acidity) within muscle or plasma, causes fatigue. The aims The present study was designed to evaluate the role of H+ and lactate- in causing muscle fatigue. Gastrocnemius muscle of Rana sp is divided into 3 groups,and each group consist of 9 muscles. Each group is submerge in 3 different type of solution. Isotonic solution+Sodium lactate (group 1), isotonic solution+lactic acid (group 2) and isotonic solution+citric acid (group 3) for 30 minutes. The muscle is being stimulated using stimulator in submaximum contraction with frekuency 5 Hz. the duration of fatigue is observed from the initiation of contraction until 50% reduction of the muscle contraction. Data is analized with ANOVA. The result of analysis showed that there were statistical differences on duration of fatigue between sodium lactate and lactic acid, between lactic acid and citric acid, and between lactic acid and citric acid (p<0,05). It was concluded that H+ accumulation plays big role in emerging muscle fatigue.
Original languageEnglish
JournalJournal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Publication statusPublished - 2010


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