The role of gut microbiota in non-alcoholic fatty liver disease: Pathways of mechanisms

Chyntia Olivia Maurine Jasirwan; Cosmas Rinaldi Adithya Lesmana; Irsan Hasan; Andri Sanityosos Sulaiman; Rino Alvani Gani

doi:10.12938/bmfh.18-032

The role of gut microbiota in non-alcoholic fatty liver disease: Pathways of mechanisms

Chyntia Olivia Maurine Jasirwan, Cosmas Rinaldi Adithya Lesmana, Irsan Hasan, Andri Sanityosos Sulaiman, Rino Alvani Gani

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.

Original language	English
Pages (from-to)	81-88
Number of pages	8
Journal	Bioscience of Microbiota, Food and Health
Volume	38
Issue number	3
DOIs	https://doi.org/10.12938/bmfh.18-032
Publication status	Published - 1 Jan 2019

Keywords

Dysbiosis
Gut microbiota
Inflammatory pathway
Metabolic pathway
NAFLD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.12938/bmfh.18-032

Cite this

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abstract = "Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.",

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AU - Jasirwan, Chyntia Olivia Maurine

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AU - Hasan, Irsan

AU - Sulaiman, Andri Sanityosos

AU - Gani, Rino Alvani

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N2 - Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.

AB - Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence increases with increasing rates of obesity, insulin resistance, and diabetes mellitus. The pathogenesis of NAFLD involves many factors, including the gastrointestinal microbiota. However, there is still debate about the impact of gut dysbiosis in the NAFLD disease progression. Therefore, this paper aims to review the relationship between gut microbiota and other risk factors for NAFLD and how gut dysbiosis plays a role in the pathogenesis of NAFLD. Hopefully, this paper can make an appropriate contribution to the development of NAFLD research in the future.

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KW - Gut microbiota

KW - Inflammatory pathway

KW - Metabolic pathway

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The role of gut microbiota in non-alcoholic fatty liver disease: Pathways of mechanisms

Abstract

Keywords

UN SDGs

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