The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening

Colorectal cancer is a malignacy with high incidence and mortality rate. The long carsinogenesis sequence from adenoma unto carsinoma enable early detection andscreening as part of the management but until recently the commercially available test has low sensitivity and specificity. M2-pyrivatekinase (M2-PK), an isomer of glycolisis enzyme involved in aerobic metabolism, is found in high amount in cancerous cell and id shed unto luminal mucosa in colorectal cancer. Qualification of this protein in fees is a promisingmethod to detect malignant lesion of colon. Several studies until recently demonstrate moderate sensitivity and specificity but clearly with better performance than commonly-used guaiac based faecal occult blood test (gFOBT).