TY - JOUR
T1 - The role of exclusive breastfeeding on sIgA and lactoferrin levels in toddlers suffering from Acute Respiratory Infection
T2 - A cross-sectional study
AU - Fatimah,
AU - Massi, Muhammad Nasrum
AU - Febriani, Andi Dwi Bahagia
AU - Hatta, Mochammad
AU - Karuniawati, Anis
AU - Rauf, Syahrul
AU - Wahyuni, Sitti
AU - Hamid, Firdaus
AU - Alasiry, Ema
AU - Patellongi, Ilham
AU - Permatasari, Tria Astika Endah
AU - Farsida,
N1 - Funding Information:
This research was funded by the Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta.
Funding Information:
This study used a structured questionnaire instrument supported by medical record data to obtain data on the characteristics of mothers and toddlers including age, gender, parity, immunization history, frequency of ARI in the last 6 months, nutritional status (weight/age), and history of EBF. The questionnaire instrument used in this study was valid and reliable. The questionnaire tested on 10% of the minimum number of samples on respondents with appropriate characteristics with participants in this study. Measurement of sIgA and lactoferrin levels was obtained from the examination of blood samples taken as much as 100 ?l, then centrifuged at 3000 rpm for 10 min to separate blood cells and serum. Blood serum was taken and put into an Eppendorf tube and stored in a freezer/refrigerator at ?80 ?C until all samples were filled. After the sample is fulfilled, it is then taken to the Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University for further examination. Examination of serum sIgA and lactoferrin levels using the Enzym linked Immunosorbent assay (ELISA) method according to the protocol of previous studies [12, 29?34].This research was funded by the Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta.
Publisher Copyright:
© 2022 The Authors
PY - 2022/5
Y1 - 2022/5
N2 - Secretion of Immunoglobulin A (sIgA) and lactoferrin is a nutrient content in breast milk that can increase immunity in preventing infectious diseases such as Acute Respiratory Infection (ARI). This research aims to determine the role of exclusive breastfeeding (EBF) on sIgA and Lactoferrin levels in toddlers suffering from ARI. A cross-sectional study was conducted on 124 toddlers under five from January–July 2021. Toddlers were selected using a purposive technique sampling from three Community Health Centers in Central Jakarta. Data were analyzed using t-test and ANOVA. The history of immunization, EBF, and frequency of ARI was significantly associated with levels of sIgA and lactoferrin. Parity only correlated with sIgA but not with lactoferrin levels. Maternal and toddlers' age, gender, and nutritional status were not significantly related to sIgA and lactoferrin levels. There is a significant (p-value <0.001) difference in the mean protein sIgA and lactoferrin levels in toddlers who were given EBF with ARI frequency <2 times and toddlers who were given EBF with ARI frequency ≥2 times. Toddlers who were exclusively breastfed with ARI frequency <2 times had higher levels of sIgA and lactoferrin (188901.77 pg/ml and 262.32 ng/ml, respectively) compared to infants given EBF with ARI frequency ≥2 times (136683.47 pg/ml and 181.49 ng/ml, respectively). History of immunization was also significantly (p-value <0.05) associated with levels of sIgA and lactoferrin in infants with ARI. The content of sIgA and lactoferrin in breast milk and immunization can increase the body's immune system in toddlers suffering from ARI.
AB - Secretion of Immunoglobulin A (sIgA) and lactoferrin is a nutrient content in breast milk that can increase immunity in preventing infectious diseases such as Acute Respiratory Infection (ARI). This research aims to determine the role of exclusive breastfeeding (EBF) on sIgA and Lactoferrin levels in toddlers suffering from ARI. A cross-sectional study was conducted on 124 toddlers under five from January–July 2021. Toddlers were selected using a purposive technique sampling from three Community Health Centers in Central Jakarta. Data were analyzed using t-test and ANOVA. The history of immunization, EBF, and frequency of ARI was significantly associated with levels of sIgA and lactoferrin. Parity only correlated with sIgA but not with lactoferrin levels. Maternal and toddlers' age, gender, and nutritional status were not significantly related to sIgA and lactoferrin levels. There is a significant (p-value <0.001) difference in the mean protein sIgA and lactoferrin levels in toddlers who were given EBF with ARI frequency <2 times and toddlers who were given EBF with ARI frequency ≥2 times. Toddlers who were exclusively breastfed with ARI frequency <2 times had higher levels of sIgA and lactoferrin (188901.77 pg/ml and 262.32 ng/ml, respectively) compared to infants given EBF with ARI frequency ≥2 times (136683.47 pg/ml and 181.49 ng/ml, respectively). History of immunization was also significantly (p-value <0.05) associated with levels of sIgA and lactoferrin in infants with ARI. The content of sIgA and lactoferrin in breast milk and immunization can increase the body's immune system in toddlers suffering from ARI.
KW - Acute respiratory infection (ARI)
KW - Exclusive breastfeeding
KW - Immunization
KW - Lactoferrin
KW - sIgA
UR - http://www.scopus.com/inward/record.url?scp=85129159797&partnerID=8YFLogxK
U2 - 10.1016/j.amsu.2022.103644
DO - 10.1016/j.amsu.2022.103644
M3 - Article
AN - SCOPUS:85129159797
SN - 2049-0801
VL - 77
JO - Annals of Medicine and Surgery
JF - Annals of Medicine and Surgery
M1 - 103644
ER -
